Intrathecal injection of CSF1 induces greater upregulation of spinal microglial genes in male versus female mice, however, Treg depletion enhances microglial activation and restores pain hypersensitivity in the female mice.

Non-specific sodium entry inhibits T cell receptor induced gene expression and differentiation of T cells by depleting intracellular ATP and disrupting mTORC2 dependent signalling axis.

IL-6 signaling in T cells controls how sensitive they are to suppression by T regulatory cells, and the way mature to become memory T cells.

The transcriptional adapter protein NCOR1 that links chromatin-modifying enzymes with gene-specific transcription factors controls naive and effector regulatory T cell states.

New roles in anti-tumour immunity for the adhesion protein Kindlin-1 via regulation of cytokine secretion and T cell regulation.

A biochemical probe targeting Tregs shows the importance of Tregs for B cell homeostasis and peripheral B cell reduction is caused by an activated T-cell-dependent mechanism.

MHC class II-mediated self-antigen presentation by lymph node stromal cells controls regulatory T cell homeostasis, thus safeguarding immune tolerance.

Natural Tr1-like cells do not form a functionally stable memory response to allergens, and this instability may limit efforts to re-establish tolerance by expanding Tr1.

Foxp3 and Ikaros, two transcription factors genetically linked to autoimmune disease in humans, cooperate to establish the epigenomic and transcriptomic landscape of regulatory T cells.

In vitro and in vivo studies show that multiple dendritic cell subsets are capable of presenting gut Helicobacter antigens to induce regulatory T cells.