A reduced tendency to update beliefs in response to positive relative to negative information predict sooner relapse in euthymic bipolar patients.

Behavioral and molecular mechanistic studies elaborate the important role of ErbB4 in noradrenergic neurons associated with mania pathogenesis.

Brain lactate and pH changes, identified as common features in diverse neuropsychiatric animal models, may represent transdiagnostic endophenotypes associated with cognitive impairment.

The antimanic action of lithium requires BDNF-TrkB signaling coupled with enhanced dynamin-dependent endocytosis of AMPARs as a potential mechanism underlying the therapeutic effects.

Applying computational modeling to quantify threat learning processes uncovers how variations in these conserved learning processes relate to anxiety severity and the neuroanatomical substrates moderating these associations.

A data-reduced neuro-behavioral geometry in psychosis spectrum disorders mapped symptoms stably on to distinct functional brain regions and offers a framework for informing personalized treatment selection decisions.

Feedback signaling between the synapse and nucleus via FGF22 and IGF2 directs the activity-dependent stabilization of presynaptic terminals in the mouse hippocampus.

Increased theta/alpha band activities within the habenula area and the prefrontal cortex, as well as the increased synchrony between the two structures in the same frequency band can serve as an indicator for negative emotions in humans.

The presynaptic active zone protein ELKS provides synapse-specific control of the pool of readily releasable vesicles and release probability.

MCTP is a novel presynaptic calcium sensor, resident within the endoplasmic reticulum, that is required for normal baseline neurotransmission, short-term synaptic plasticity and presynaptic homeostatic plasticity.