In vivo study of arbovirus infections reveals the dominant role of pDC IRF7-signaling in directing both type I and II IFN responses, and leading to viral control.

Molecular architecture of the secreted NS1 dimer from dengue virus infection in complex with a high density lipoprotein particle.

An inadequate engagement of the inflammation resolution circuit centred on Annexin A1 contributes to the excessive inflammation observed in severe DENV infection, suggesting FPR2/ALX agonists as a therapeutic target for dengue disease.

Single-particle studies of dengue-virus membrane fusion and the effect of small-molecule inhibitors of infection clarify the viral fusion mechanism.

Identification of viral and host determinants of broadly neutralizing antibodies targeting a new epitope on dengue virus that can be used to guide vaccine design.

Building on previous work (St John et al., 2013), we explain why secondary infection by dengue virus is associated with more severe vascular disease than primary infection.

Proteins produced by mast cells modulate the permeability of blood vessels, and may determine whether patients infected with dengue virus develop life-threatening complications.

Talaromyces (Tsp_PR) fungus render Aedes aegypti mosquitoes more susceptible to dengue virus infection through secreted molecules that impair midgut digestive enzyme transcription and activity.

Age-specific incidence data, combined with mechanistic models of immunity, provides a unique opportunity to characterize disease transmission of dengue and other immunizing diseases at high temporal and spatial resolution.

A combination of surveillance data, paired sera and mathematical modelling reveals which factors may influence dengue transmission and control in island settings.