An integrated biochemical and evolutionary analysis shows how enzyme specificity evolves after gene loss during genome decay, implicating relaxation of purifying selection as a driving force for functional divergence.

Parallel losses of short-wave light sensitivity in diverse bats occurred through independent changes at multiple steps in the conversion of genotype into functional phenotype, including pre-, during, and post-transcription.

The genomic features associated with a gene fate to loss have been retained for approximately 500 million years during evolution, and the genes with these features exhibit restricted expression profiles, leading to the genes being less important.

The short lifetime of orphan genes is a major factor explaining the stability of gene number in Drosophila.

The genomes of animal progenitors evolved as mosaics of old, new, rearranged, and repurposed protein domains, genes and pathways and paved the way for the origin and evolution of animals.

The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.

Loss-of-function mutations in human genes are an important class of disease causing variation, and estimates of their effects on evolutionary fitness can be used to evaluate their pathogenicity.

Analysis of chromerid algal genomes reveals how apicomplexans have evolved from free-living algae into successful eukaryotic parasites via massive losses and re-inventing functional roles of genes.

The gene regulatory network of Nodal signaling, underpinning body axes patterning, was evolved specifically in cephalochordate lineage.

Islands of non-methylated DNA are shown to perform a similar epigenetic role in many different vertebrate species.