Delayed inhibition precisely balances excitation from arbitrary combinations of CA3 neurons and controls the gain of CA1 output by reducing inhibitory delay with increasing excitation.
Christoph Wiest, Flavie Torrecillos ... Huiling Tan
The slope of the power spectrum of subthalamic local field potentials tracks pathological states in Parkinson’s disease and likely complements beta activity as a feedback marker for adaptive deep brain stimulation.
Computational modeling and analysis of mouse neural population data finds that the excitation/inhibition imbalance theory of brain disorders is too limited to account for key changes in neural activity statistics.
Cristina Gil Avila, Elisabeth S May ... Markus Ploner
Multiverse analysis of the aperiodic component of the electroencephalography (EEG) power spectrum yielded robust evidence against a relationship to chronic pain, guiding further research on EEG biomarkers of chronic pain.
David GT Barrett, Sophie Denève, Christian K Machens
Spiking networks compensate the loss of neurons instantaneously, when restoration of excitatory/inhibitory balance becomes equivalent to restoration of functionality.
Sebastián Giunti, María Gabriela Blanco ... Diego Rayes
PTEN mutations disrupt inhibitory GABAergic signaling, causing neurodevelopmental defects that can be mitigated by β-hydroxybutyrate, which activates DAF-16/FOXO and may offer a therapeutic approach for excitation/inhibition imbalances.
The formation and refinement of prediction error circuits relies on an experience-dependent balance of excitation and inhibition in canonical microcircuits.