1,213 results found
    1. Neuroscience
    2. Medicine

    Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

    Stavros Trakoshis, Pablo Martínez-Cañada ... Michael V Lombardo
    Excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic males versus females.
    1. Neuroscience

    Precise excitation-inhibition balance controls gain and timing in the hippocampus

    Aanchal Bhatia, Sahil Moza, Upinder Singh Bhalla
    Delayed inhibition precisely balances excitation from arbitrary combinations of CA3 neurons and controls the gain of CA1 output by reducing inhibitory delay with increasing excitation.
    1. Neuroscience

    The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism

    Christoph Wiest, Flavie Torrecillos ... Huiling Tan
    The slope of the power spectrum of subthalamic local field potentials tracks pathological states in Parkinson’s disease and likely complements beta activity as a feedback marker for adaptive deep brain stimulation.
    1. Neuroscience

    Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders

    Cian O'Donnell, J Tiago Gonçalves ... Terrence J Sejnowski
    Computational modeling and analysis of mouse neural population data finds that the excitation/inhibition imbalance theory of brain disorders is too limited to account for key changes in neural activity statistics.
    1. Neuroscience

    Assessing the balance between excitation and inhibition in chronic pain through the aperiodic component of EEG

    Cristina Gil Avila, Elisabeth S May ... Markus Ploner
    Multiverse analysis of the aperiodic component of the electroencephalography (EEG) power spectrum yielded robust evidence against a relationship to chronic pain, guiding further research on EEG biomarkers of chronic pain.
    1. Neuroscience

    Optimal compensation for neuron loss

    David GT Barrett, Sophie Denève, Christian K Machens
    Spiking networks compensate the loss of neurons instantaneously, when restoration of excitatory/inhibitory balance becomes equivalent to restoration of functionality.
    1. Developmental Biology
    2. Neuroscience

    The ketone body β-hydroxybutyrate ameliorates neurodevelopmental deficits in the GABAergic system of daf-18/PTEN Caenorhabditis elegans mutants

    Sebastián Giunti, María Gabriela Blanco ... Diego Rayes
    PTEN mutations disrupt inhibitory GABAergic signaling, causing neurodevelopmental defects that can be mitigated by β-hydroxybutyrate, which activates DAF-16/FOXO and may offer a therapeutic approach for excitation/inhibition imbalances.
    1. Neuroscience

    Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys

    Miki Kaneshige, Kei Obara ... Yukio Nishimura
    Spinal stimulation at balanced currents of excitation and inhibition boosts voluntarily produced torque production.
    1. Neuroscience

    Learning prediction error neurons in a canonical interneuron circuit

    Loreen Hertäg, Henning Sprekeler
    The formation and refinement of prediction error circuits relies on an experience-dependent balance of excitation and inhibition in canonical microcircuits.

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