470 results found
    1. Microbiology and Infectious Disease

    High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy

    Claudia A Vera-Arias, Aurel Holzschuh ... Cristian Koepfli
    A novel high-throughput method for Plasmodium falciparum genotyping will enable malaria control programs to make informed decisions about the best tool to use for the diagnosis of malaria.
    1. Epidemiology and Global Health

    Modelling the drivers of the spread of Plasmodium falciparum hrp2 gene deletions in sub-Saharan Africa

    Oliver J Watson, Hannah C Slater ... Azra C Ghani
    The introduction of rapid diagnostic testing for Plasmodium falciparum infections can explain an increased emergence of diagnostic resistant pfhrp2-deleted parasites in sub-Saharan Africa.
    1. Microbiology and Infectious Disease

    Interchromosomal segmental duplication drives translocation and loss of P. falciparum histidine-rich protein 3

    Nicholas J Hathaway, Isaac E Kim ... Jeffrey A Bailey
    Sequence analyses show a pfhrp3 deletion mechanism involves duplication of chromosome 11 segment, which is normally removed via negative selection, and specific conditions are needed for spread including low transmission.
    1. Epidemiology and Global Health

    FnCas9-based CRISPR diagnostic for rapid and accurate detection of major SARS-CoV-2 variants on a paper strip

    Manoj Kumar, Sneha Gulati ... Debojyoti Chakraborty
    A newly developed lateral flow assay can diagnose mutational signatures of major SARS CoV-2 variants in a rapid, inexpensive, and sequence-free manner.
    1. Epidemiology and Global Health

    Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions

    Oliver John Watson, Robert Verity ... Hannah C Slater
    The timing of surveillance for pfhrp2/3-deletions within a transmission season impacts estimates of the proportion of false-negative RDTs due to deletions, which may cause premature decisions to change RDT.
    1. Microbiology and Infectious Disease

    Saliva TwoStep for rapid detection of asymptomatic SARS-CoV-2 carriers

    Qing Yang, Nicholas R Meyerson ... Sara L Sawyer
    A quick and portable test makes saliva samples turn yellow when people are carrying SARS-CoV-2, the virus that causes COVID-19.
    1. Epidemiology and Global Health

    Efficacy profile of the CYD-TDV dengue vaccine revealed by Bayesian survival analysis of individual-level phase III data

    Daniel J Laydon, Ilaria Dorigatti ... Neil M Ferguson
    Bayesian survival analysis reveals comprehensive efficacy profile and mechanism of action for Sanofi-Pasteur’s CYD-TDV dengue vaccine, whereby vaccination acts as a silent, disease-free infection enhancing disease risk in seronegatives, but giving greater immunity in seropositives than two natural infections.
    1. Structural Biology and Molecular Biophysics

    Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood

    Nicole Toepfner, Christoph Herold ... Jochen Guck
    The morphology and deformability of all blood cells can be measured continuously and with high throughput directly in whole blood without prior enrichment or separation.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study

    Oliver Stirrup, James Blackstone ... Judith Breuer
    Sequencing of viral genomes could be useful for infection prevention and control within hospitals, but did not lead to a reduction in the rate of hospital-acquired SARS-CoV-2 infections over winter 2020/2021 in a large multicentre UK study.
    1. Microbiology and Infectious Disease

    Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals

    Rodrigo M Young, Camila J Solis ... Luis A Quiñones
    PCR testing for SARS-CoV-2 from samples taken from smartphone screens, Phone Screen Testing, provides a sensitive, cost-effective, simple, and non-invasive new method that could boost COVID-19 mass test screening.

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