816 results found
    1. Neuroscience

    Proof of concept for multiple nerve transfers to a single target muscle

    Matthias Luft, Johanna Klepetko ... Konstantin Davide Bergmeister
    A murine model for a novel surgical concept demonstrates potential advances of neuroprosthetic interfacing.
    1. Developmental Biology
    2. Medicine

    Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat

    Jingyi Chi, Zeran Lin ... Paul Cohen
    The regulation of sympathetic innervation density by beige adipocytes in subcutaneous fat is important during a critical developmental window, but dispensable during adulthood.
    1. Cell Biology
    2. Developmental Biology

    Innervation modulates the functional connectivity between pancreatic endocrine cells

    Yu Hsuan Carol Yang, Linford JB Briant ... Didier YR Stainier
    Intercellular communication is critical for organ function, and the role of innervation in mediating this communication is of relevance to many fields, including developmental biology, neuroendocrinology, and disease pathophysiology.
    1. Cell Biology
    2. Developmental Biology

    A new mode of pancreatic islet innervation revealed by live imaging in zebrafish

    Yu Hsuan Carol Yang, Koichi Kawakami, Didier YR Stainier
    A novel mode of organ innervation, whereby neurons establish connections with their targets before migrating away, was revealed by live imaging of the developing zebrafish pancreas.
    1. Medicine

    Senescence of endplate osteoclasts induces sensory innervation and spinal pain

    Dayu Pan, Kheiria Gamal Benkato ... Xu Cao
    Depleting senescent osteoclasts using the senolytic drug Navitoclax (ABT263) can reduce sensory innervation in the endplate and attenuate low back pain, thus representing a potent therapy for treating spinal pain.
    1. Developmental Biology
    2. Neuroscience

    Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

    Simon Desiderio, Frederick Schwaller ... Frederic Marmigere
    Combining mouse genetic, behavioral, and electrophysiological approaches revealed that a transcription factor is required to shape touch neurons' distal projections in the skin while dispensable for their survival and specification.
    1. Neuroscience

    Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus

    Francois M Lambert, Laura Cardoit ... Didier Le Ray
    Molecular labeling, electrophysiology and calcium imaging have revealed a novel switching of neurotransmitter at the frog neuromuscular junction where motoneurons transiently release glutamate before acetylcholine at synapses on developing hindlimb muscles at the onset of metamorphosis.
    1. Neuroscience

    Cell-type specific innervation of cortical pyramidal cells at their apical dendrites

    Ali Karimi, Jan Odenthal ... Moritz Helmstaedter
    The composition of inhibitory and excitatory synaptic inputs to the apical dendrites of pyramidal cells in mouse cortex is specific to the type of pyramidal cells.
    1. Neuroscience

    Balance between BDNF and Semaphorins gates the innervation of the mammary gland

    Hadas Sar Shalom, Ron Goldner ... Avraham Yaron
    The innervation of the mammary gland is controlled by opposing effects of neurotrophic and repulsive factors and, once trophic signaling is inhibited the repulsive factors, may promote axonal pruning.
    1. Neuroscience

    Dynamic neuromuscular remodeling precedes motor-unit loss in a mouse model of ALS

    Éric Martineau, Adriana Di Polo ... Richard Robitaille
    Motor axons undergo dynamic branch-specific changes for weeks before complete neuronal degeneration in a model of amyotrophic lateral sclerosis, highlighting the importance of peripheral factors, intrinsic and extrinsic to motoneurons.

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