The regulation of sympathetic innervation density by beige adipocytes in subcutaneous fat is important during a critical developmental window, but dispensable during adulthood.
Yu Hsuan Carol Yang, Linford JB Briant ... Didier YR Stainier
Intercellular communication is critical for organ function, and the role of innervation in mediating this communication is of relevance to many fields, including developmental biology, neuroendocrinology, and disease pathophysiology.
Yu Hsuan Carol Yang, Koichi Kawakami, Didier YR Stainier
A novel mode of organ innervation, whereby neurons establish connections with their targets before migrating away, was revealed by live imaging of the developing zebrafish pancreas.
Depleting senescent osteoclasts using the senolytic drug Navitoclax (ABT263) can reduce sensory innervation in the endplate and attenuate low back pain, thus representing a potent therapy for treating spinal pain.
Simon Desiderio, Frederick Schwaller ... Frederic Marmigere
Combining mouse genetic, behavioral, and electrophysiological approaches revealed that a transcription factor is required to shape touch neurons' distal projections in the skin while dispensable for their survival and specification.
Francois M Lambert, Laura Cardoit ... Didier Le Ray
Molecular labeling, electrophysiology and calcium imaging have revealed a novel switching of neurotransmitter at the frog neuromuscular junction where motoneurons transiently release glutamate before acetylcholine at synapses on developing hindlimb muscles at the onset of metamorphosis.
The composition of inhibitory and excitatory synaptic inputs to the apical dendrites of pyramidal cells in mouse cortex is specific to the type of pyramidal cells.
The innervation of the mammary gland is controlled by opposing effects of neurotrophic and repulsive factors and, once trophic signaling is inhibited the repulsive factors, may promote axonal pruning.
Éric Martineau, Adriana Di Polo ... Richard Robitaille
Motor axons undergo dynamic branch-specific changes for weeks before complete neuronal degeneration in a model of amyotrophic lateral sclerosis, highlighting the importance of peripheral factors, intrinsic and extrinsic to motoneurons.