Genetic analyses in mice identifies Rlim in the spermatogenic cell lineage as a regulator of cytoplasmic reduction during spermiogenesis.

HIPK4 is a male germ cell-enriched kinase that regulates cytoskeletal rearrangements in spermatids during spermiogenesis and is required for male fertility in mice.

Augmentation of progestin signaling promotes testis development and spermatogenesis independent from andorgen signaling in zebrafish.

The discovery of X chromosome-associated protein 5 (Xap5)-mediated transcriptional rewiring of ciliary genes in animals reveals that this regulatory mechanism was conserved during evolution.

The rapidly evolving X-linked MIR-506 family miRNAs function to enhance sperm competitiveness and male reproductive fitness in mice.

Mitochondrial functional and structural defects caused by PARL deficiency lead to arrested spermatogenesis and germ cell ferroptosis.

SSH2, a Slingshot phosphatase required for male fertility, participates in acrosome biogenesis via the control of actin remodeling during spermatid development.

Germline extrachromosomal circular DNAs are mainly formed by microhomology-mediated ligation of nucleosome-protected fragments and barely contribute to de novo genomic deletions at meiotic recombination hotspots.

Triglyceride plays an important role in regulating sperm development.

Androglobin, a newly identified mammalian globin with a unique modular structure including a protease and calmodulin binding IQ domain within a circularly permuted globin domain, is implicated in murine spermatogenesis.