The conductance-based encoding model creates a new bridge between statistical models and biophysical models of neurons, and infers visually-evoked excitatory and inhibitory synaptic conductances from spike trains in macaque retina.
HDAC SUMOylation promotes the association of other chromatin remodeling factors with the nuclear Argonaute WAGO-9, which is required for de novo heterochromatin silencing.
Katy AM Gaythorpe, Arran Hamlet ... Neil M Ferguson
Analysis of yellow fever burden in Africa illustrates the need to consider the effect of a changing climactic conditions when planning future intervention strategies.
PIE-1 engages SUMO to preserve the embryonic germline fate and also to promote the assembly of a MEP-1/Mi-2/HDA-1 chromatin remodeling complex required for inherited Argonaute-mediated gene silencing in the adult hermaphrodite germline.
Yellow fever, a potentially deadly viral hemorrhagic fever, causes up to 82,000 deaths annually worldwide, and mass vaccination activities have reduced the burden by 47% in Africa.
Basal ganglia output neurons use the NALCN leak channel to maintain their characteristic tonic firing, and this channel is important for the modulation of firing by metabolic or receptor-mediated signals.
Carlos Manlio Díaz-García, Dylan J Meyer ... Gary Yellen
When neurons are stimulated, calcium entry into mitochondria upregulates mitochondrial energy production, but glycolytic energy production in the cytosol is stimulated by elevated energy demand, not Ca2+ signaling.