15,850 results found
    1. Neuroscience

    Inferring synaptic inputs from spikes with a conductance-based neural encoding model

    Kenneth W Latimer, Fred Rieke, Jonathan W Pillow
    The conductance-based encoding model creates a new bridge between statistical models and biophysical models of neurons, and infers visually-evoked excitatory and inhibitory synaptic conductances from spike trains in macaque retina.
    1. Developmental Biology

    HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans

    Heesun Kim, Yue-He Ding ... Craig C Mello
    HDAC SUMOylation promotes the association of other chromatin remodeling factors with the nuclear Argonaute WAGO-9, which is required for de novo heterochromatin silencing.
    1. Epidemiology and Global Health

    The effect of climate change on yellow fever disease burden in Africa

    Katy AM Gaythorpe, Arran Hamlet ... Neil M Ferguson
    Analysis of yellow fever burden in Africa illustrates the need to consider the effect of a changing climactic conditions when planning future intervention strategies.
    1. Genetics and Genomics

    PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans

    Heesun Kim, Yue-He Ding ... Craig C Mello
    PIE-1 engages SUMO to preserve the embryonic germline fate and also to promote the assembly of a MEP-1/Mi-2/HDA-1 chromatin remodeling complex required for inherited Argonaute-mediated gene silencing in the adult hermaphrodite germline.
    1. Developmental Biology

    Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice

    Jorge López-Tello, Vicente Pérez-García ... Amanda N Sferruzzi-Perri
    Fetus and trophoblast interplay to regulate fetal nutrient supply and, ultimately, affect healthy growth.
    1. Neuroscience

    Clonally related, Notch-differentiated spinal neurons integrate into distinct circuits

    Saul Bello-Rojas, Martha W Bagnall
    Pairs of spinal cord neurons arising from a shared progenitor get input from and make outputs to mostly different synaptic partners.
    1. Epidemiology and Global Health

    The global burden of yellow fever

    Katy AM Gaythorpe, Arran Hamlet ... Neil Ferguson
    Yellow fever, a potentially deadly viral hemorrhagic fever, causes up to 82,000 deaths annually worldwide, and mass vaccination activities have reduced the burden by 47% in Africa.
    1. Neuroscience

    The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons

    Andrew Lutas, Carolina Lahmann ... Gary Yellen
    Basal ganglia output neurons use the NALCN leak channel to maintain their characteristic tonic firing, and this channel is important for the modulation of firing by metabolic or receptor-mediated signals.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The yellow gene influences Drosophila male mating success through sex comb melanization

    Jonathan H Massey, Daayun Chung ... Patricia J Wittkopp
    Melanization of a secondary sexual structure facilitates male mating success in Drosophila.
    1. Neuroscience

    The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle

    Carlos Manlio Díaz-García, Dylan J Meyer ... Gary Yellen
    When neurons are stimulated, calcium entry into mitochondria upregulates mitochondrial energy production, but glycolytic energy production in the cytosol is stimulated by elevated energy demand, not Ca2+ signaling.

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