Browse our latest Cancer Biology articles

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    1. Cancer Biology
    2. Cell Biology

    Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling

    Benjamin L Ricca et al.
    In a 3D culture model of breast epithelium, application of a short-timescale compression to single malignant cells promotes the long-timescale development of polarized, growth-arrested structures.
    1. Cancer Biology
    2. Cell Biology

    Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs

    Saori Furuta et al.
    Endogenous laminins are necessary to build a functional acinus via generating NO, activating p53, HOXD10 and other positive players, but tumor cells neither make laminin nor generate NO, unless they are reverted to an organized structure.
    1. Cancer Biology

    Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

    Simeon U Springer et al.
    The creation of a non-invasive assay for detecting urothelial cancer could have a profound impact on how we find and treat the disease.
    1. Cancer Biology

    Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

    John Repass, Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
    1. Cancer Biology

    Reproducibility in Cancer Biology: The who, where and how of fusobacteria and colon cancer

    Cynthia L Sears
    The association between the bacterium Fusobacterium nucleatum and human colon cancer is more complicated than it first appeared.
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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

    Karl P Hodel et al.
    When mismatch repair is compromised heterozygous loss of Pol ε proofreading is sufficient to drive a subset of the observed clinical characteristics of Pol ε tumors.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain

    Kelda Chia et al.
    Pre-neoplastic cells in the brain release SDF1, which mediates an immediate infiltration of macrophages that differentiate into microglia-like cells and promote proliferation of pre-neoplastic cells.
    1. Cancer Biology

    Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers

    Xuehui Hong et al.
    A Methylation-Phosphorylation Switch Determines RioK1 Stability and Function in CRC and GC Progression.
    1. Cancer Biology

    LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer

    Pang-Kuo Lo et al.
    LIPG, a lipoprotein lipase, executes its oncogenic function in human basal-like triple-negative breast cancer through its functional involvement in DTX3L-ISG15 signaling, an interferon-related pathway that regulates protein functionality by ISGylation.
    1. Cancer Biology
    2. Developmental Biology and Stem Cells

    Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation

    Chee Wai Chua et al.
    Analyses of genetically engineered mouse models reveal the androgen receptor-independent properties of a luminal stem/progenitor cell in the prostate epithelium, and its ability to serve as a cell of origin for castration-resistant prostate cancer.