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Page 2 of 26
Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation
Kelda Chia et al.
P2ry12-mediated microglial interactions stimulate the proliferation of brain tumour initiating cells.
The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in
Jean-Philippe Parvy et al.
Natural activity of the antimicrobial peptide Defensin includes execution of tumour cell death by tumour necrosis factor in
R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma
Jeroen Overman et al.
Identification of the R(+)-propranolol enantiomer as an inhibitor of the SOX18 transcription factor activity breaks open potential of drug repurposing in vascular diseases.
A positive feedback loop between Myc and aerobic glycolysis sustains tumor growth in a
Kenneth Kin Lam Wong et al.
Specific molecular links that orchestrate growth signals and metabolic reprogramming to achieve tumorigenesis are identified as potential metabolic vulnerabilities in cancer treatment.
Club cells form lung adenocarcinomas and maintain the alveoli of adult mice
Magda Spella et al.
Airway cells are required for the maintenance of the adult mouse lung and for carcinogen-induced lung adenocarcinoma development, and are thus marked therapeutic targets.
NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma
Ganapati V Hegde et al.
TP63 regulates NRG1 in squamous cell cancers, and targeting of NRG1 induces cancer cell differentiation thereby NRG1 is a potential therapeutic target in squamous cell cancers.
Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer
SungEun Kim et al.
Pharmacologic inhibition of DNA methylation restrains the growth of urothelial carcinoma by subtype conversion through heightened stromal Hedgehog pathway activity.
KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D
Sawan Kumar Jha et al.
Both VEGF-C and VEGF-D can be activated by KLK3/PSA and Cathepsin D, producing two novel VEGF-C forms and the known VEGFR-2-specific form of VEGF-D.
Biochemistry and Chemical Biology
Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer
Yun Pyo Kang et al.
By increasing intracellular cysteine levels, NRF2 engages a tumor suppressive metabolic pathway mediated by cysteine dioxygenase 1.
Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
Anthony Essex et al.
Editors' Summary: This Replication Study has reproduced important parts of the original paper.
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