Browse our latest Cancer Biology articles

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    1. Cancer Biology

    RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway

    Fang Huang, Zhenwei Dai ... Yang Wang
    RBM7 functions as a novel regulator of MFGE8 alternative splicing and p65 phosphorylation to counteract the metastatic potential of breast cancer, offering novel mechanistic insights into how abnormal splicing contributes to tumor aggressiveness.
    1. Genetics and Genomics
    2. Cancer Biology

    Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases

    Joakim Karlsson, Vasu R Sah ... Jonas A Nilsson
    1. Immunology and Inflammation
    2. Cancer Biology

    Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence

    Kai Sha, Renyuan Zhang ... John J Krolewski
    1. Cancer Biology

    NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model

    Ismail M Meraz, Mourad Majidi ... Jack A Roth
    1. Cancer Biology
    2. Immunology and Inflammation

    DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

    Nicholas J Mullen, Surendra K Shukla ... Pankaj K Singh
    Cancer cell antigen presentation, a requirement for immune-mediated tumor rejection, is induced by dihydroorotate dehydrogenase-inhibitor-mediated cancer cell pyrimidine nucleotide depletion via P-TEFb-dependent transcriptional upregulation of MHC-I and related genes.
    1. Cancer Biology

    PITAR, a DNA damage-inducible Cancer/Testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

    Samarjit Jana, Mainak Mondal ... Kumaravel Somasundaram
    1. Cancer Biology

    Dual Targeting of Histone Deacetylases and MYC as Potential Treatment Strategy for H3-K27M Pediatric Gliomas

    Danielle Algranati, Roni Oren ... Efrat Shema
    1. Cancer Biology
    2. Cell Biology

    CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake

    Savvas Nikolaou, Amelie Juin ... Laura M Machesky
    Macropinocytosis of the signalling receptor LPAR1, by an actin and CYRI-B-dependent mechanism, impacts on progression and spread of pancreatic cancer in a mouse model.
    1. Developmental Biology
    2. Cancer Biology

    VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent transcription and tumorigenesis by engaging p300

    Susu Guo, Xiaodi Hu ... Junhao Mao
    1. Cancer Biology

    Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer

    Eugine Lee, Zeda Zhang ... Charles L. Sawyers
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