Browse our latest Cancer Biology articles

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    1. Cancer Biology

    Cancer Risk: Why do women with melanoma do better than men?

    Keiran SM Smalley
    Harnessing female sex hormones may improve how all patients with melanoma respond to treatment.
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    1. Cancer Biology

    Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade

    Christopher A Natale et al.
    Driving melanoma differentiation through G protein-coupled estrogen receptor signaling decreases proliferative capacity, decreases expression of the oncodriver and stem cell marker c-Myc, and increases the effectiveness of immunotherapy.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Reproducibility in Cancer Biology: Getting to grips with c-Myc

    Dirk Eick
    The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.
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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc

    L Michelle Lewis et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper, but it also contains results that are not consistent with some parts of the original paper.
    1. Cancer Biology
    2. Genes and Chromosomes

    Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells

    John P Vanden Heuvel et al.
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
    1. Cancer Biology
    2. Cell Biology

    LAST, a c-Myc-inducible long noncoding RNA, cooperates with CNBP to promote CCND1 mRNA stability in human cells

    Limian Cao et al.
    A c-Myc-transcribed long noncoding RNA namely LAST (LncRNA-assisted stabilization of transcripts) collaborates with a cellular factor CNBP to promote the stability of CCND1/cyclin D1 mRNA post-transcriptionally, ensuring the proper G1/Sphase transition of the cell cycle.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia

    Xiaodong Zhang et al.
    The survival and growth of solid tumor cells in hypoxia is dependent on fatty acid storage in triglyceride lipid droplets promoted by HIG2.
    1. Biophysics and Structural Biology
    2. Cancer Biology

    A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression

    Elliot C Woods et al.
    Mucins, long associated with cancer aggression, remodel the cancer glycocalyx in a way that promotes proliferation in the metastatic site by enhancing integrin-mediated adhesion and thus driving cell cycle progression.
    1. Cancer Biology
    2. Developmental Biology and Stem Cells

    Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth

    Tiemo J Klisch et al.
    Aberrant phosphorylation of tyrosine 78 on Atoh1 via Jak2 is responsible for sonic hedgehog type medulloblastoma growths in vivo.
    1. Cancer Biology

    Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation

    Angela M Halstead et al.
    Bladder-cancer-associated RXRA mutations were found to stimulate urothelial proliferation through a mechanism susceptible to small molecule inhibitors of Peroxisome Proliferator-Activated Receptors, credentialing a new class of targetable drivers of bladder cancer.