YEATS2 and GCDH are upregulated in head and neck cancer in an SP1-dependent manner, leading to enhanced levels of promoter histone crotonylation which in turn elevates expression of EMT-associated SPARC.
Glycolysis and attenuates oxidative phosphorylation through long-chain fatty acids, while mitochondrial biogenesis and anabolism remain intact, to accelerate the progression of acute megakaryocytic leukemia.
A novel, non-invasive strategy combining radiomics and blood extracellular vesicle-derived microRNA profiling to sharpen pancreatic cancer diagnosis is introduced.
Abundant single-stranded telomeric DNA distinguishes alternative lengthening of telomeres-positive cells and represents a potential biomarker and therapeutic vulnerability.
The promotion of C1QBP accumulation by PA28γ leads to the malignant progression of tumor by affecting mitochondrial function, which could be a launch pad for therapeutic intervention of tumor development.
