Browse our latest Cancer Biology articles

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    1. Genetics and Genomics
    2. Cancer Biology

    Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma

    Olivia G Waltner, April A Apfelbaum ... Scott N Furlan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Cancer Biology

    JAK-STAT Pathway Heterogeneity Governs Immunotherapy Response in Breast Cancer

    Jianbo Zhou, Heng Zhang ... Fu Peng
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Convincing
    1. Cancer Biology
    2. Cell Biology

    DuoHexaBody-CD37 induces direct cytotoxic signaling in diffuse large B-cell lymphoma

    Simar Pal Singh, Kumar Mangalam ... Annemiek B van Spriel
    DuoHexaBody‑CD37 triggers complement‑independent cytotoxic signaling in diffuse large B-cell lymphoma (DLBCL), revealing therapeutic pathways that can be exploited to enhance tumor cell killing through targeted combination strategies.
    1. Cancer Biology

    Tumor Biology: The two faces of JAK-STAT

    Qianying Lu, Yingyi Zhang
    A signal that can help breast cancer cells grow may also increase immune responses and boost immune therapy.
    Version of Record
    Insight
    1. Cancer Biology

    PCNA-Polκ-Polδ/USP18 axes stabilize replication fork and restart to reduce cisplatin cytotoxicity

    Ipsita Subhadarsini, Jugal Kishor Sahu ... Narottam Acharya
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation
    2. Cancer Biology

    Integrin-deficient T cell leukemia accumulates in the central nervous system

    Samantha Y Lux, Cynthia Chen ... Susan R Schwab
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Cancer Biology

    Restraint of melanoma progression by cells in the local skin environment

    Yilun Ma, Mohita Tagore ... Richard M White
    Keratinocytes, which activate an EMT-like program in the skin, can prevent melanoma invasion, highlighting how changes in the tumor microenvironment can act as restraining forces in cancer.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Epigenetic and 3D Genome Changes Drive Primary Trastuzumab Resistance in HER2+ Breast Cancer

    Ningjun Duan, Yijia Hua ... Yongmei Yin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

    Ariunaa Bayanjargal, Cenny Taslim ... Emily Rose Theisen
    A discrete helix in the fusion oncoprotein DNA binding domain shifts binding preferences toward long and dense GGAA repeats, which promotes transcriptional hub formation and drives EWSR1::FLI1-mediated gene regulation.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

    Chiara Asselborn, Agata N Makar ... Alexander von Kriegsheim
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
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