Browse our latest Cancer Biology articles

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    1. Cancer Biology

    Precision RNAi using synthetic shRNAmir target sites

    Thomas Hoffmann, Alexandra Hörmann ... Ralph A. Neumüller
    1. Medicine
    2. Cancer Biology

    International multicenter study comparing COVID-19 in patients with cancer to patients without cancer: Impact of risk factors and treatment modalities on survivorship

    Issam I Raad, Ray Hachem ... Anne-Marie Chaftari
    Remdesivir is a promising treatment modality to reduce 30 day all-cause mortality.
    1. Cancer Biology
    2. Medicine

    Long COVID in cancer patients: preponderance of symptoms in majority of patients over long time period

    Hiba Dagher, Anne-Marie Chaftari ... Issam I Raad
    Long COVID occurred in the majority of cancer patients diagnosed with acute COVID-19 with a preponderance of symptoms (such as fatigue, sleep disturbances, and gastrointestinal symptoms) over a long time period.
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    1. Cancer Biology
    2. Immunology and Inflammation

    Proliferative exhausted CD8+ T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma

    Danni Cheng, Ke Qiu ... Jianjun Ren
    Multi-omic profiling of tumor-infiltrating T cells provides new insights into the differences in the effectiveness of CDK4 inhibitor between human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma patients.
    1. Cancer Biology

    The role of macrophages in non-small cell lung cancer and advancements in 3D co-cultures

    Katarína Balážová, Hans Clevers, Antonella FM Dost
    As macrophages are involved in various aspects of non-small cell lung cancer development and progression it is crucial to develop appropriate 3D co-culture platforms for modeling immune cell-tumor cell interactions, leading to more efficacious macrophage-focused immunotherapies.
    1. Cancer Biology

    Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms

    Gary KL Chan, Samantha Maisel ... John D Gordan
    Protein kinase A-driven increases in c-MYC protein expression and tumor cell proliferation can be blocked by eIF4A inhibitors, suggesting a potential new treatment option for patients with oncogenic PKA activation.
    1. Cancer Biology
    2. Developmental Biology

    Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells

    Deepti Prasad, Katharina Illek ... Anne-Kathrin Classen
    Deregulated cell fate specification pathways, including oncogenic Ras, cause activation of JNK-signaling at contact sites with wild type cells, which drives apoptosis and aberrant cell elimination in a contact-dependent manner.
    1. Cancer Biology

    Selective androgen receptor degrader (SARD) to overcome antiandrogen resistance in castration-resistant prostate cancer

    Meng Wu, Rongyu Zhang ... Jinming Zhou
    The rational drug design combining the bioassay identified a novel selective androgen receptor (AR) degrader for both AR and AR-VRs and illustrated the synergistic importance of AR antagonism and degradation in advanced prostate cancer treatment.
    1. Cancer Biology
    2. Cell Biology

    ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

    Kimberly J Morgan, Karen Doggett ... Joan K Heath
    ELYS, a multifunctional protein with critical roles in the cell cycle, is essential for the vigorous proliferation and survival of difficult-to-treat cancers carrying mutations in the KRAS oncogene, making it a compelling target for novel drug treatments.
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    Beta human papillomavirus 8E6 promotes alternative end joining

    Changkun Hu, Taylor Bugbee ... Nicholas Wallace
    Human papillomavirus type 8 E6 promotes alternative end joining by compromising non-homologous end joining and homologous recombination.