Browse our latest Cancer Biology articles

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    1. Cancer Biology
    2. Cell Biology

    Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timing

    Lauren K Williams et al.
    Cytoplasmic bodies sequester important abscission machinery to delay completion of cytokinesis in response to mitotic errors.
    1. Cancer Biology

    A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

    Joanna L Gillis et al.
    A positive feedback loop between the androgen receptor and a key pentose phosphate pathway enzyme, 6PGD, in prostate cancer promotes tumour cell proliferation, survival and intracellular redox control.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

    Satoshi Takahashi et al.
    Interaction of the MLL and HBO1 complexes is a key nexus for leukemic transformation that can serve as a therapeutic target.
    1. Cancer Biology
    2. Medicine

    Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

    S Jordan Kerns et al.
    Novel human models of the lung and intestine are described and validated as preclinical in vitro tools for predictive profiling of T-cell-bispecific antibodies with expected on-target off-tumor risk.
    1. Cancer Biology

    NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

    Carolina Marques et al.
    Neurofibromatosis type 1 gene (NF1) signaling is causally linked to the acquisition of a mesenchymal gene expression program in gliomas through the regulation of the AP-1 transcription factor FOSL1.
    1. Cancer Biology
    2. Cell Biology

    CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions

    Veethika Pandey et al.
    Blockage of CXCL10/CXCR3 signaling between murine pancreatic precancerous lesion cells and inflammatory macrophages generates a tumor-promoting microenvironment.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Autoregulatory control of microtubule binding in doublecortin-like kinase 1

    Regina L Agulto et al.
    Doublecortin-like kinase 1 modulates its own kinase activity to tune its microtubule-binding affinity, providing molecular insights into a unique form of autoregulatory control over microtubule-binding activity.
    1. Cancer Biology
    2. Medicine

    Association of human breast cancer CD44-/CD24- cells with delayed distant metastasis

    Xinbo Qiao et al.
    CD44-/CD24- breast cancer cells contribute to delayed postoperative distant metastasis by their spontaneous conversion into CD44+/CD24- breast cancer stem cells (CSCs).