Browse our latest Cancer Biology articles

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    1. Cancer Biology

    Causal associations between human plasma proteins and prostate cancer identified by proteome-wide Mendelian randomization

    Lin Chen, Yanlun Gu ... Xiaocong Pang
    The identification of 20 causal plasma proteins for prostate cancer represents a critical step toward addressing the need for improved diagnostic specificity and reveals promising new targets for therapeutic intervention.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

    Richard C Centore, Luis MM Soares ... Steven F Bellon
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Compelling
    1. Computational and Systems Biology
    2. Cancer Biology

    Single-Cell Atlas of AML Reveals Age-Related Gene Regulatory Networks in t(8;21) AML

    Jessica Whittle, Stefan Meyer ... Mudassar Iqbal
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Rearrangement of 3D genome organization in breast cancer epithelial to mesenchymal transition and metastasis organotropism

    Priyojit Das, Rebeca San Martin ... Rachel Patton McCord
    Chromosome compartment analysis of a cancer cell line cohort reveals different subsets of compartment changes where some track epithelial to mesenchymal transition while others reflect secondary metastatic organ-specific reorganizations.
    1. Cancer Biology

    PTEN restrains SHH medulloblastma growth through cell autonomous and nonautonomous mechanisms

    Zhimin Lao, Salsabiel El Nagar ... Alexandra L Joyner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cancer Biology

    Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

    Jessica Armand, Sungsoo Kim ... Hee Won Yang
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Cancer Biology

    Multi-gradient Permutation Survival Analysis Identifies Mitosis and Immune Signatures Steadily Associated with Cancer Patient Prognosis

    Xinlei Cai, Yi Ye ... Hongbin Ji
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Developmental Biology
    2. Cancer Biology

    Tumors mimic the niche to inhibit neighboring stem cell differentiation

    Yang Zhang, Yuejia Wang ... Shaowei Zhao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cancer Biology

    TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer

    Laura Morano, Nadia Vezzio-Vié ... Jihane Basbous
    Pharmacological disruption of TopBP1 condensation impairs ATR signaling, promotes DNA damage and apoptosis, and enhances the efficacy of FOLFIRI chemotherapy in colorectal cancer.
    1. Cancer Biology

    Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain

    Cassandra C Taber, Wenguang He ... Michael Ohh
    A unique pathogenic mutation on the primary prolyl hydroxylase of the oxygen-sensing pathway compromises the capacity to hydroxylate the hypoxia-inducible factor's N-terminal oxygen-dependent degradation domain proline while retaining activity against the otherwise catalytically predominant C-terminal proline.
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