Browse our latest Cancer Biology articles

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    1. Cancer Biology

    Nerve Injury-Induced Protein 2 preserves lysosomal membrane integrity to suppress ferroptosis

    Jin Zhang, Miranda Bustamante ... Xinbin Chen
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration in human cancer cells

    Ravi Kumar, Simon Couly ... Ashish Lal
    Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.
    1. Cell Biology
    2. Cancer Biology

    HER2-driven mammary tumorigenesis enhances bioenergetics despite reductions in mitochondrial content

    Sara M Frangos, Henver S Brunetta ... Graham P Holloway
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

    Siying Zeng, Yuqi Wang ... Xun Hu
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Cancer Biology

    Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in lung adenocarcinoma

    Gaoming Liao, Xinbin Yang ... Gang Xu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cancer Biology

    Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

    Yanping Li, Xiaoxin Xie ... Qionghua Zhu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synthetic gene circuits that selectively target RAS-driven cancers

    Gabriel Valentin Senn, Leon Nissen, Yaakov Benenson
    Design and integration of various biomolecular sensors for over-activated rat sarcoma (RAS) created synthetic gene circuits that distinguish mutant versus wild-type signaling and express a therapeutic protein to kill RAS-driven cancer cells.
    1. Cell Biology
    2. Cancer Biology

    Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

    David Papadopoli, Ranveer Palia ... Ivan Topisirovic
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

    Ariunaa Bayanjargal, Cenny Taslim ... Emily R Theisen
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Computational and Systems Biology
    2. Cancer Biology

    End-to-end proteogenomics for discovery of cryptic and non-canonical cancer proteoforms using long-read transcriptomics and multi-dimensional proteomics

    Katarzyna Kulej, Asher Preska Steinberg ... Alex Kentsis
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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