Browse our latest Cancer Biology articles

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    1. Cancer Biology
    2. Neuroscience

    Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation

    Kelda Chia et al.
    P2ry12-mediated microglial interactions stimulate the proliferation of brain tumour initiating cells.
    1. Cancer Biology
    2. Developmental Biology

    The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila

    Jean-Philippe Parvy et al.
    Natural activity of the antimicrobial peptide Defensin includes execution of tumour cell death by tumour necrosis factor in Drosophila.
    1. Cancer Biology

    R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma

    Jeroen Overman et al.
    Identification of the R(+)-propranolol enantiomer as an inhibitor of the SOX18 transcription factor activity breaks open potential of drug repurposing in vascular diseases.
    1. Cancer Biology
    2. Cell Biology

    A positive feedback loop between Myc and aerobic glycolysis sustains tumor growth in a Drosophila tumor model

    Kenneth Kin Lam Wong et al.
    Specific molecular links that orchestrate growth signals and metabolic reprogramming to achieve tumorigenesis are identified as potential metabolic vulnerabilities in cancer treatment.
    1. Cancer Biology
    2. Cell Biology

    Club cells form lung adenocarcinomas and maintain the alveoli of adult mice

    Magda Spella et al.
    Airway cells are required for the maintenance of the adult mouse lung and for carcinogen-induced lung adenocarcinoma development, and are thus marked therapeutic targets.
    1. Cancer Biology

    NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma

    Ganapati V Hegde et al.
    TP63 regulates NRG1 in squamous cell cancers, and targeting of NRG1 induces cancer cell differentiation thereby NRG1 is a potential therapeutic target in squamous cell cancers.
    1. Cancer Biology

    Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

    SungEun Kim et al.
    Pharmacologic inhibition of DNA methylation restrains the growth of urothelial carcinoma by subtype conversion through heightened stromal Hedgehog pathway activity.
    1. Cancer Biology

    KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D

    Sawan Kumar Jha et al.
    Both VEGF-C and VEGF-D can be activated by KLK3/PSA and Cathepsin D, producing two novel VEGF-C forms and the known VEGFR-2-specific form of VEGF-D.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

    Yun Pyo Kang et al.
    By increasing intracellular cysteine levels, NRF2 engages a tumor suppressive metabolic pathway mediated by cysteine dioxygenase 1.
    1. Cancer Biology

    Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

    Anthony Essex et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.