Browse our latest Cancer Biology articles

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    1. Cancer Biology
    2. Immunology and Inflammation

    Cancer genome and tumor microenvironment: Reciprocal crosstalk shapes lung cancer plasticity

    Siavash Mansouri, Daniel Heylmann ... Rajkumar Savai
    The crosstalk between cancer cell genomic features and the tumor microenvironment (TME) to reveal the impact of genetic alterations on the TME phenotype.
    1. Cancer Biology
    2. Immunology and Inflammation

    Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer

    Yuexin Wang, Hui Yang ... Guangwei Liu
    Detailed in vivo and in vitro experimental data in mice and human cell experimental data provide critical insight for understanding the role of the DC-based mechanical regulation of immunopathology in directing T cell lineage commitment in tumor microenvironments.
    1. Cancer Biology

    Genetically manipulating endogenous Kras levels and oncogenic mutations in vivo influences tissue patterning of murine tumorigenesis

    Özgün Le Roux, Nicole LK Pershing ... Christopher M Counter
    Altering the level of different oncogenic mutants of Kras induces unique tumor patterns in mice, suggesting that tissue-specific responses mold the sensitivity of normal tissues to different oncogenic RAS mutations.
    1. Cancer Biology
    2. Cell Biology

    EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation

    Ariel Pribluda, Anneleen Daemen ... Melissa R Junttila
    G9a regulates chromatin-bound b-catenin enabling cell-intrinsic control of WNT signaling-mediated cell fate decisions.
    1. Cancer Biology
    2. Cell Biology

    Nuclear fascin regulates cancer cell survival

    Campbell D Lawson, Samantha Peel ... Maddy Parsons
    Nuclear fascin accumulation occurs upon inhibition of Histone H3 kinases and results in enhanced and sustained nuclear F-actin bundling leading to reduced cancer cell invasion, viability, and nuclear fascin-specific/driven apoptosis.
    1. Cancer Biology

    Hypoxia-inducible factor underlies von Hippel-Lindau disease stigmata

    Michael Ohh, Cassandra C Taber ... Daniel Tarade
    Previous studies and emerging data on pseudohypoxic diseases suggest that the complex phenotypic spectrum of VHL disease is due to the extent of HIF pathway deregulation in susceptible cell types and not by other purported substrates or functions of pVHL.
    1. Cancer Biology

    AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer

    Seaho Kim, CheukMan C Au ... Paraskevi Giannakakou
    Advanced microscopy techniques reveal unique biological features that distinguish androgen receptor variant 7 (AR-V7) from the canonical AR, including high intranuclear mobility and rapid nuclear import that occurs independently of importin-α/β.
    1. Cancer Biology
    2. Computational and Systems Biology

    Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments

    Zan He, Zijuan Xin ... Hua Zhao
    A single-cell landscape of acral melanoma and the intermolecular regulatory relationships between microenvironments.
    1. Cancer Biology

    Androgen Receptor: How splicing confers treatment resistance in prostate cancer

    Prathyusha Konda, Srinivas R Viswanathan
    A splice variant of the androgen receptor that drives prostate cancer resistance translocates into the nucleus using a different mechanism from the full-length receptor and exhibits distinct molecular properties once inside.
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