Browse our latest Cancer Biology articles

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    1. Cancer Biology

    Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer

    Xin Zhang, Guangyu Zhang ... Chunjie Liu
    iCAF-mediated immune escape and promoted tumor angiogenesis via VEGFA/B-VEGFR1 pathway indicate that a combination of immunotherapies and anti-angiogenic targeted therapy may be effective for H. pylori infection-associated gastric cancer.
    1. Cancer Biology
    2. Cell Biology

    RUNX2 isoform II protects cancer cells from ferroptosis and apoptosis by promoting PRDX2 expression in oral squamous cell carcinoma

    Junjun Huang, Rong Jia, Jihua Guo
    Upregulated by HOXA10, RUNX2 isoform II transactivates PRDX2 expression and inhibits ferroptosis and apoptosis in oral squamous cell carcinoma.
    1. Cancer Biology

    PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

    Jiongke Wang, Yujie Shi ... Qianming Chen
    Revised
    Reviewed Preprint v4
    Updated
    • Important
    • Solid
    1. Computational and Systems Biology
    2. Cancer Biology

    BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment

    Emilio Rios-Jimenez, Anoek Zomer ... Maria Alieva
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Cell Biology
    2. Cancer Biology

    PRMT1-Mediated Metabolic Reprogramming Promotes Leukemogenesis

    Hairui Su, Yong Sun ... Xinyang Zhao
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cancer Biology

    Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab-resistant HER2-positive breast cancer

    Yijia Hua, Ningjun Duan ... Yongmei Yin
    Targeting cysteine metabolism could provide novel strategies for treating trastuzumab-resistant HER2-positive breast cancer.
    1. Cancer Biology

    Reduced mitochondrial transcription sensitizes acute myeloid leukemia cells to BCL-2 inhibition

    Laleh S Arabanian, Jenni Adamsson ... Claes M Gustafsson
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology

    Ferroptosis-related genes mediate tumor microenvironment and prognosis in triple-negative breast cancer via integrated RNA-seq analysis

    Xuantong Gong, Lishuang Gu ... Yong Wang
    Integrated single-cell RNA-seq analysis identifies ferroptosis-driven tumor microenvironment features, enabling a prognostic risk model and therapeutic targets to advance precision medicine for triple-negative breast cancer.
    1. Cancer Biology
    2. Cell Biology

    Image-based identification and isolation of micronucleated cells to dissect cellular consequences

    Lucian DiPeso, Sriram Pendyala ... Emily M Hatch
    The development of an automated micronucleus segmentation program enables population-level comparisons between cells with and without micronuclei and defines a highly limited response to micronucleus formation or rupture.
    1. Cancer Biology

    NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer

    Shengsheng Zhao, Ji Lin ... Weijian Sun
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Solid