Browse our latest Cancer Biology articles

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    1. Cancer Biology

    Design of combination therapeutics from protein response to drugs in ovarian cancer cells

    Alexandra Franz, Ciyue Shen ... Chris Sander
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cancer Biology

    Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in FGFR2-amplified gastric cancer

    Yue Zhang, Hanbing Wang ... Yue Wang
    Dual blocking SHP2 and FGFR2 can not only promote the targeted tumor-killing effects and overcome FGFR2 inhibitor resistance caused by feedback activation, but also activate T cell-mediated anti-tumor immunity.
    1. Computational and Systems Biology
    2. Cancer Biology

    Systematic Analysis of Network-driven Adaptive Resistance to CDK4/6 and Estrogen Receptor Inhibition using Meta-Dynamic Network Modelling

    Anthony Hart, Sung-Young Shin, Lan K Nguyen
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Cancer Biology

    Turning aging cells into a live vaccine: engineered senescent cancer cells with adjuvant celecoxib for immunotherapy

    Yuewei Wang, Ante Ou ... Yongzhuo Huang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology

    Nerve Injury-Induced Protein 2 preserves lysosomal membrane integrity to suppress ferroptosis

    Jin Zhang, Miranda Bustamante ... Xinbin Chen
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration in human cancer cells

    Ravi Kumar, Simon Couly ... Ashish Lal
    Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.
    1. Cell Biology
    2. Cancer Biology

    HER2-driven mammary tumorigenesis enhances bioenergetics despite reductions in mitochondrial content

    Sara M Frangos, Henver S Brunetta ... Graham P Holloway
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

    Siying Zeng, Yuqi Wang ... Xun Hu
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Cancer Biology

    Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in lung adenocarcinoma

    Gaoming Liao, Xinbin Yang ... Gang Xu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cancer Biology

    Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

    Yanping Li, Xiaoxin Xie ... Qionghua Zhu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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