Browse our latest Cancer Biology articles

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    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai et al.
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.
    1. Cancer Biology

    Supervised mutational signatures for obesity and other tissue-specific etiological factors in cancer

    Bahman Afsari et al.
    A supervised methodology for mutational signatures outperforms the current standard unsupervised approach revealing new tissue-dependent mutational signatures among which some for obesity.
    1. Cancer Biology
    2. Genetics and Genomics

    MITF reprograms the extracellular matrix and focal adhesion in melanoma

    Ramile Dilshat et al.
    Analysis of knockout and knockdown melanoma cells and TCGA melanoma data shows that the microphthalmia-associated transcription factor (MITF) is a major repressor of extracellular matrix (ECM) and focal adhesion genes.
    1. Cancer Biology

    Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

    Paul Guilhamon et al.
    Chromatin-based cancer stem cell heterogeneity typifies primary glioblastoma and includes an invasive subtype associated with a lower survival.
    1. Cancer Biology

    The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

    Jacob T Polaski et al.
    UPF1 mutations were reportedly present at high frequencies in a cohort of pancreatic adenosquamous carcinoma patients, but these lesions are unlikely to be functional drivers of this cancer subtype.
    1. Cancer Biology
    2. Cell Biology

    Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

    Shima Ghoroghi et al.
    A combination of animal models reveal how the molecular mechanisms of exosome secretion (RalA/B-dependent) are linked to their cargo content and their function in breast cancer pre-metastatic niche formation.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium

    Madeline Sandoval et al.
    Skin epithelium can tolerate oncogene-expressing clones through a novel cellular mechanism of inter-clonal competition between renewing progenitors along the clone's edge and differentiating progenitors within the clone's core.
    1. Cancer Biology

    Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism

    Krystal Ann Orlando et al.
    BRG1 loss drives initiation and progression in human cancers through changes in specific differentiation programs in an AP-1-dependent manner.
    1. Cancer Biology

    Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging

    Takahisa Maruno et al.
    Genetic lineage tracing approach combined with live imaging visualized the functional stem cell activity of Doublecortin-like kinase 1+ cells within pancreatic cancer in vivo.