Chromosomal instability of cancer can be quantitatively measured by phylogenetic analysis of 200 tumor cells while using evolutionary principles to account for cellular selection.
A mathematical model of colorectal cancer initiation shows that a change in cells’ kinetic parameters due to aspirin can account for an observed reduction in advanced adenoma age- incidence in patients treated with aspirin.
Replication stress induces phosphorylation events within RIF1 intrinsically disordered region that are essential for RIF1's role in DNA replication fork protection.
Enzyme tethering of promiscuous biotinylators to the cell surface allows for more rapid and efficient comparative surface proteomic analysis of cells and extracellular vesicles.
Mucosal-associated invariant T cells, an emerging member of the innate-like T cells abundant in humans bridging the innate and the adaptive immunity, could be exploited as a novel tool for cancer immunotherapy through cell reprogramming.
In a mouse model of neurofibromatosis type 1, the purinergic receptor P2RY14 is a key regulator of Schwann cell precursor self-renewal and proliferation, of neurofibroma tumor initiation and of mouse survival.
Papillomavirus E7 proteins activate the YAP1 oncogene in basal epithelial cells by degrading PTPN14, in doing so promoting basal cell retention and contributing to carcinogenesis.
A twofold increased risk of adverse outcomes (mortality, ICU admission, and severity of COVID-19) has been demonstrated in unvaccinated COVID-19 patients with cancer compared to COVID-19 patients without cancer.