Keratinocytes, which activate an EMT-like program in the skin, can prevent melanoma invasion, highlighting how changes in the tumor microenvironment can act as restraining forces in cancer.
Ariunaa Bayanjargal, Cenny Taslim ... Emily Rose Theisen
A discrete helix in the fusion oncoprotein DNA binding domain shifts binding preferences toward long and dense GGAA repeats, which promotes transcriptional hub formation and drives EWSR1::FLI1-mediated gene regulation.
BRCA1/2 mutations rewire the lung adenocarcinoma microenvironment through distinct immune programs, with BRCA1-linked type I interferon signaling and CD8+ T activation contrasting BRCA2-linked MHC-II antigen presentation and CD4+ T differentiation.
Drosophila female germline tumors mutant for bam or bgcn mimic the stem cell niche to inhibit the differentiation of neighboring wild-type germline stem cells.
