Browse our latest Cancer Biology articles

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    1. Cancer Biology

    Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging

    Takahisa Maruno et al.
    Genetic lineage tracing approach combined with live imaging visualized the functional stem cell activity of Doublecortin-like kinase 1+ cells within pancreatic cancer in vivo.
    1. Cancer Biology

    MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

    Tessa M Popay et al.
    Interaction of oncoprotein transcription factor MYC with chromatin-associated protein host cell factor–1 controls expression of genes important for ribosome biogenesis and mitochondrial vigor, loss of which promotes tumor regression.
    1. Cancer Biology

    Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy

    Richard Lee Barrett, Ellen Puré
    Long under-appreciated, fibroblast biology is a key aspect of understanding how the immune system responds to tumors and may hold the key to improving immunotherapy in this tricky space.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Cohesin mutations are synthetic lethal with stimulation of WNT signaling

    Chue Vin Chin et al.
    Hypersensitivity of cohesin-deficient cells to Wnt signaling is concomitant with beta catenin stabilization and offers promise that Wnt agonists could be therapeutically effective in cohesin mutant cancers.
    1. Cancer Biology
    2. Structural Biology and Molecular Biophysics

    Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants

    Adam R Blanden et al.
    p53 folding is critically dependent on zinc, and a synthetic metallochaperone rescues tumorigenic mutations that reduce p53's zinc affinity as well as thermodynamic stability.
    1. Cancer Biology

    TINF2 is a haploinsufficient tumor suppressor that limits telomere length

    Isabelle Schmutz et al.
    Mutations in TIN2, a component of shelterin that keeps telomere length in check, lead to cancer-predisposition by disabling the telomere tumor suppressor pathway.
    1. Cancer Biology
    2. Cell Biology

    A versatile system to record cell-cell interactions

    Rui Tang et al.
    A novel reporter system that employs cell surface antigen-nanobody pairing enables physical interaction-dependent labeling and functional modification between diverse cell types.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

    Xiao Ling Li et al.
    Discovery and initial characterization of a conserved small protein translated from a transcript annotated as a human long non-coding RNA.
    1. Cancer Biology

    eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis

    Hang Ruan et al.
    Genetic and transcriptomic analyses revealed that eIF4E S209 phosphorylation enables Myc and mutant KRAS cooperation in colon cancer through stress- and glutamine-dependent growth and addiction.
    1. Cancer Biology

    Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

    Nataša Pavlović et al.
    Inhibiting IRE1α decreases tumor cell proliferation and migration in hepatocellular carcinoma, therefore components of this ER-stress pathway may be therapeutically relevant for liver cancer.