Browse our latest Cancer Biology articles

A mouse model reveals that a p53 SNP impacts longevity via modulating the balance of cancer risk and the self-renewal function of stem/progenitor cells, which supports a role of p53 in regulation of longevity.

SPIN1, a nucleolar protein, plays an oncogenic role by suppressing the tumor suppressor p53's function via regulation of the uL18-MDM2-p53 pathway.

A long non-coding RNA molecule called cherub is a driver of tumor development.

Genetic analyses uncovered that the asymmetrically long non-coding RNA cherub is required for brain tumor growth.

In a 3D culture model of breast epithelium, application of a short-timescale compression to single malignant cells promotes the long-timescale development of polarized, growth-arrested structures.

Endogenous laminins are necessary to build a functional acinus via generating NO, activating p53, HOXD10 and other positive players, but tumor cells neither make laminin nor generate NO, unless they are reverted to an organized structure.

The creation of a non-invasive assay for detecting urothelial cancer could have a profound impact on how we find and treat the disease.

Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.

The association between the bacterium Fusobacterium nucleatum and human colon cancer is more complicated than it first appeared.

When mismatch repair is compromised heterozygous loss of Pol ε proofreading is sufficient to drive a subset of the observed clinical characteristics of Pol ε tumors.