Browse our latest Chromosomes and Gene Expression articles

Genetic analysis combined with whole genome sequencing elucidates mechanisms and pathways that form and prevent a specific class of genome rearrangements, foldback inversions, seen in many human cancers.

Ubiquitylation of the CMG helicase is inhibited throughout the initiation and elongation phases of chromosome replication by the DNA structure of a replication fork.

Disruption of the nucleosome DNA entry-exit site causes readthrough transcription of terminators, decreased nucleosome occupancy, and pervasive noncoding transcription, demonstrating this nucleosomal region protects the genome against inappropriate transcription.

Characterization of Drosophila female germ cell differentiation shows that nurse cells initiate Polycomb silencing by regulating Pcl and Scm levels to alter the biochemical properties of the PRC2 H3K27 methylase.

RNA does not form DNA:RNA hybrids in trans that compromise genome integrity.

H3K23me3 is a RNAi-mediated transgenerationally heritable heterochromatin mark in Caenorhabditis elegans.

Human telomerase unfolds and extends parallel G-quadruplexes using a unique mechanism involving its RNA template.

Mitochondria can tune the protein synthesis of nuclear-encoded proteins through condition-dependent mRNA localization that is regulated by translation elongation and the geometric constraints of the cell.

Cell-cycle progression is crucial for heterochromatin formation in budding yeast because S phase promotes the removal of active chromatin marks.

The mechanism of Dbf4-dependent kinase (DDK) recruitment to replication origins and its regulation by the checkpoint have been identified.