Browse our latest Immunology and Inflammation articles

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    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    One N-glycan regulates natural killer cell antibody-dependent cell-mediated cytotoxicity and modulates Fc γ receptor IIIa/CD16a structure

    Paul G Kremer, Elizabeth A Lampros ... Adam W Barb
    Multiple lines of evidence demonstrate that a single N-glycan on one receptor influences the strength of a cytotoxic response elicited by natural killer cells following stimulation with an antibody-coated target.
    1. Immunology and Inflammation

    Heat Shock Factor Regulation of Antimicrobial Peptides Expression Suggests a Conserved Defense Mechanism Induced by Febrile Temperature in Arthropods

    Bang Xiao, Shihan Chen ... Chaozheng Li
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Immunology and Inflammation

    Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor

    Chenchen Mao, Yanyu Chen ... Xiangyang Xue
    Resting natural killer cells promote the progress of colon cancer liver metastasis (CCLM), which may be exploited for novel strategies to improve therapeutic outcomes for patients with CCLM.
    1. Immunology and Inflammation
    2. Neuroscience

    Transcriptional responses in a mouse model of silicone wire embolization induced acute retinal artery ischemia and reperfusion

    Yuedan Wang, Ying Li ... Xuan Xiao
    The UPOAO model effectively replicates retinal ischemia in retinal artery occlusion, providing a novel platform for identifying pathogenic genes and advancing therapeutic research.
    1. Immunology and Inflammation

    PD-1 negatively regulates helper T cell differentiation into Th2

    Masaki Tajima, Naoko Ikuta ... Akio Ohta
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    • Incomplete
    1. Cancer Biology
    2. Immunology and Inflammation

    A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets

    Akashdip Singh, Alberto Miranda Bedate ... Linde Meyaard
    A bioinformatics pipeline describes 390 putative, novel inhibitory receptors, to facilitate targeted therapeutic strategies for diverse immune cell types in cancer therapy.
    1. Immunology and Inflammation

    LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization

    Hyun-Chae Lee, Sun-Hee Park ... Kyoung Seob Song
    PEGylated PDZ peptide reduces LPS-induced systemic inflammation, restores tissue integrity, decreases pro-inflammatory cytokines, and modulates macrophage populations, showing potential as a therapeutic for systemic inflammation.
    1. Immunology and Inflammation

    A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

    Yuji Miyatake, Tomokatsu Ikawa ... Ai Kotani
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Peptidoglycan-Chi3l1 interaction shapes gut microbiota in intestinal mucus layer

    Yan Chen, Ruizhi Yang ... Zhao Shan
    Chi3l1 binds to bacterial peptidoglycan, helping anchor and organize bacteria within the mucus layer.
    1. Cancer Biology
    2. Immunology and Inflammation

    Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

    Jianwen Chen, Bao Zhao ... Haitao Wen
    Deficiency or pharmacological inhibition of O-glcNac transferase (OGT) enhances tumor immunity in colorectal cancer models.
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