Interleukin-1 activates RhoA/ROCK signaling, which drives the enrichment of actin bundles at the cell-cell junctions, preventing SARS-CoV-2 spreading via syncytia formation.
Gut microbiota from young mice can alleviate gout and hyperuricemia in aged mice, further revealing that the metabolic product butyrate derived from the gut microbiota exerts similar therapeutic effects.
IL-15/IL-12-conditioned syngeneic natural killer cells induce long-term survival of tumor-resected mice with established low-burden metastases via activation of dendritic and T cells in the metastatic lung.
Patsy R Tomlinson, Rachel G Knox ... Robert K Semple
PIK3R1 mutations that cause immunodeficiency through PI3-kinase hyperactivation also cause SHORT syndrome, due to PI3-kinase hypofunction, attributable to PI3-kinase destabilisation and outcompetition by mutant PIK3R1.
Sofia V Krasik, Ekaterina A Bryushkova ... Ekaterina O Serebrovskaya
BCR profiling of tumor infiltrating B cells alongside with circulating and lymph node-resident B cells deepens understanding of their unique properties.
A naturally acquired human monoclonal antibody recognizes proteins expressed at different stages of the Plasmodium falciparum life cycle through affinity-matured homotypic interactions with glutamate-rich repeats.
Aryeh Solomon, Noa Bossel Ben-Moshe ... Roi Avraham
In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.
