Browse our latest Immunology and Inflammation articles

The simultaneous delivery of protein and lipid antigens via nanoparticles may help efforts to develop a new vaccine for tuberculosis.

Androgen receptor activation modifies B cell frequencies and functionality, accompanied by weight gain in female mice exposed to human PCOS IgG, highlighting the unrecognized involvement of B cells in PCOS autoimmune comorbidities despite their absence not preventing PCOS phenotype development.

Bactericidal/permeability-increasing protein (BPI) from the scorpionfish Sebastes schlegelii escapes detection by BPI autoantibodies derived from people with cystic fibrosis and reveals excellent anti-inflammatory potency as well as profound antimicrobial activity towards Pseudomonas aeruginosa, including multiple drug-resistant strains.

In an autoimmune environment B cells mature from spontaneous germinal centers into transcriptomically and phenotypically diverse memory and antibody-secreting cells but maintaining shared clonal and potential self-reactive specificities which has important implications for pathogenic cell targeted depletion.

The results presented here indicate that IL-10-producing CD4⁺ T cells express genes associated with chronically activated T_H1-like cells, undergo clonal expansion, and inhibit antiviral T cell responses via the secretion of arginase-1, facilitating viral persistence in mice infected with MCMV.

A road to modulators of the kinase activity and the non-enzymatic functions of Src and IDO1 at once.

Manipulating cell death in situ with the temporal and spatial precision of optogenetic tools opens up new avenues for studying inflammation, death and related phenomena, revealing, for example, that epithelial cell death cannot be classified into strictly distinct categories.

Two-photon microscopy, combined with chemotaxis assays, synchronized thymocyte selection studies, and flow cytometry analyses, reveal that CCR4 and CCR7 promote medullary entry and central tolerance of immature and mature post-positive selection thymocyte subsets, respectively, with distinct outcomes for central tolerance.

The endoplasmic reticulum (ER) folding sensor UGGT1 essentially cooperates with the peptide editor TAPBPR to provide quality control of MHC I molecules in the antigen presentation pathway.

Prolonged CD4⁺ and CD8⁺ T-cell activation and long COVID symptoms at 3 months post hospitlization independently associate with severe COVID-19, and ongoing T-cell activation does not affect the generation and maintenance of memory T-cell and antibody responses to SARS-CoV-2.