Patients with microsatellite stable/low microsatellite instability mismatch repair-proficient metastatic colorectal cancer may be sensitive to tislelizumab treatment after receiving Gamma Knife stereotactic radiotherapy.
Joanna Kosinska, Julian C Assmann ... Markus Schwaninger
The therapeutic effect of dimethyl fumarate in experimental autoimmune encephalomyelitis depends on the diet of mice and is mediated by the G protein-coupled receptor HCAR2 in neutrophils.
Identification of two molecularly distinct retroperitoneal liposarcoma subtypes, stratifiable via LEP and PTTG1 biomarkers, enables prognosis prediction and informs precision surgical strategies to improve clinical outcomes.
Philip Stavrides, Chris N Goulbourne ... Dun-Sheng Yang
ALP alterations in Q175 brains are late-onset, mild, existing at the later phases of the pathway, and stimulating autophagy at early disease progression enhances mHTT clearance to ameliorate HD pathology.
Kate Gunther, Teagan Fisher ... Caroline Elizabeth Ford
Nearly half of sequencing data labeled as endometriosis lacks true disease representation, highlighting the urgent need for more diverse and accurate tissue sampling to advance research in this underrepresented field.
AARS2 safeguards cardiomyocytes against ischemic injury by modulating PKM2-driven energy metabolism, revealing the AARS2-PKM2 axis as a previously unrecognized cardioprotective pathway in myocardial infarction.
