Browse our latest Medicine articles

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    1. Medicine

    eLife and Medicine: Rigorous review and editorial oversight of clinical preprints

    Mone Zaidi et al.
    Research in many different areas of medicine will benefit from new approaches to peer review and publishing.
    Editorial
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    1. Epidemiology and Global Health
    2. Medicine

    A high rate of COVID-19 vaccine hesitancy in a large-scale survey on Arabs

    Eyad A Qunaibi et al.
    Providing important data regarding the proportion of COVID-19 vaccine hesitancy and barriers toward vaccination in Arabic-speaking people to guide addressing the problem and achievement of widespread vaccination and collective immunity.
    1. Medicine

    The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry

    Melanie Castro-Mollo et al.
    The hepcidin regulator erythroferrone functions by sequestering BMPs and is an important modulator of bone remodeling, providing new mechanistic insight into how premature osteoporosis persists in optimally transfused β-thalassemic patients.
    1. Cell Biology
    2. Medicine

    Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs

    Srinu Tumpara et al.
    Finding that circulating Z alpha-1 antitrypsin polymers, a feature of ZZ AAT deficiency, lower the expression of CX3CR1 on peripheral blood mononuclear cells encourages more detailed analyses on different circulating misfolded proteins and their role on immune cell surveillance/function.
    1. Cell Biology
    2. Medicine

    Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

    Yang Zhang et al.
    Identifying xanthohumol and its derivatives as PPARγ anatagonists provides new insight into how natural compounds beneficially treat obesity and metabolic syndrome, and provide new compounds for therapeutic development.
    1. Genetics and Genomics
    2. Medicine

    Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

    Yi Liu et al.
    Systematic quantification of abdominal organ health parameters using deep learning generates new insights into the genetic architecture of cardiometabolic health traits.
    1. Genetics and Genomics
    2. Medicine

    Tendon and motor phenotypes in the Crtap-/- mouse model of recessive osteogenesis imperfecta

    Matthew William Grol et al.
    Ultrastructural, biochemical, and behavioral assessments reveal that the Crtap-/- mouse model of severe, recessive Osteogenesis Imperfecta presents with defects in tendon structure and strength that correlate with severe motor deficits.
    1. Computational and Systems Biology
    2. Medicine

    Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction

    Muhammad Arif et al.
    Elucidating widespread and tissue-specific biological process alterations after myocardial infaction in metabolically active tissues using systems biology approaches.
    1. Computational and Systems Biology
    2. Medicine

    Heart Attack: Working together

    Regan Odongo, Tunahan Çakır
    Heart attacks have a ripple effect on how other organs exchange biomolecules that help the heart respond to injury.
    Insight
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    1. Epidemiology and Global Health
    2. Medicine

    Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

    Heli Julkunen et al.
    Metabolic biomarkers measured from single blood test can identify apparently healthy people at high susceptibility for developing severe pneumonia, and may also be useful for preventive COVID-19 screening.