Browse our latest Medicine articles

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    1. Computational and Systems Biology
    2. Medicine

    Individual variation in Achilles tendon morphology and geometry changes susceptibility to injury

    Nai-Hao Yin et al.
    Studying individual Achilles tendon geometry and interface sliding capacity may allow prediction of injury sites, and targeted training on specific muscle-(sub-)tendon units may boost beneficial outcomes for Achilles tendinopathy.
    1. Immunology and Inflammation
    2. Medicine

    Cytokine ranking via mutual information algorithm correlates cytokine profiles with presenting disease severity in patients infected with SARS-CoV-2

    Kelsey E Huntington et al.
    A mutual information algorithm points to macrophage activation syndrome as a specific pathogenic mechanism in COVID-19, correlated with disease severity, which could be used to monitor disease and therapeutics.
    1. Computational and Systems Biology
    2. Medicine

    Reproducible analysis of disease space via principal components using the novel R package syndRomics

    Abel Torres-Espín et al.
    A tutorial and open-source software to aid in reproducible disease pattern detection using principal component analysis.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice

    Jumpei Ito et al.
    Iron derived from autophagy-mediated ferritin degradation in response to pressure overload induces lipid peroxidation, necrotic cardiomyocyte death, and heart failure in mice.
    1. Cell Biology
    2. Medicine

    Research: A new era for research into aging

    Matt Kaeberlein, Jessica K Tyler
    eLife is publishing a special issue on aging, geroscience and longevity to mark the rapid progress made in this field over the past decade, both in terms of mechanistic understanding and translational approaches that are poised to have clinical impact on age-related diseases.
    Editorial
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    1. Immunology and Inflammation
    2. Medicine

    Methotrexate attenuates vascular inflammation through an adenosine-microRNA-dependent pathway

    Dafeng Yang et al.
    Investigation into methotrexate's effects in the vascular endothelium reveals it exerts anti-inflammatory effects through a unique adenosine-adenosine receptor A3-SMAD3/4-miR-181b signaling axis with implications for controlling vascular inflammation.
    1. Evolutionary Biology
    2. Medicine

    A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females

    Brooke Zanco et al.
    Micronutrients, not macronutrients, regulate lifespan.
    1. Biochemistry and Chemical Biology
    2. Medicine

    The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

    Omar Al Rifai et al.
    In mice, but not in humans, the bone-derived hormone osteocalcin is O-glycosylated, a post-translational modification controlling its half-life in vivo.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Bone Hormones: Survival of the glycosylated

    Harry C Blair, Paul H Schlesinger
    Osteocalcin is a bone matrix protein that acts like a hormone when it reaches the blood, and has different effects in mice and humans.
    Insight
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