Browse our latest Medicine articles

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    1. Medicine
    2. Microbiology and Infectious Disease

    Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

    Nguyen Lam Vuong et al.
    Relationships of biomarkers with clinical outcome differed between children and adults and the best combinations associated with moderate/severe dengue comprised of six/seven vascular and immune biomarkers.
    1. Computational and Systems Biology
    2. Medicine

    NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism

    Homa MohammadiPeyhani et al.
    NICEdrug.ch is a resource allowing systematic and large-scale computational analysis of drug biochemistry, enzymatic targets, and toxicity in the context of cellular metabolism.
    1. Genetics and Genomics
    2. Medicine

    EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence

    Jeremie Gautheron et al.
    Disruption of epoxide hydrolysis inducing oxidative stress and cellular senescence is a novel mechanism responsible for lipoatrophic monogenic diabetes.
    1. Immunology and Inflammation
    2. Medicine

    Expansion of CD10neg neutrophils and CD14+HLA-DRneg/low monocytes driving proinflammatory responses in patients with acute myocardial infarction

    Daniela Fraccarollo et al.
    Immature CD10neg neutrophils and CD14+HLA-DRneg/low monocytes inducing proinflammatory and adaptive immune responses emerge in patients with large acute myocardial infarction.
    1. Medicine

    Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics

    Julia Stokes et al.
    Volatile anesthetics impair hepatic tricarboxylic acid cycle function in adult and neonatal mice, with citrate accumulation driving a neonate-specific inhibition of beta-oxidation and ketosis through their increased relative sensitivity to malonyl-CoA.
    1. Medicine

    7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

    Fan Xue et al.
    In vitro and in vivo studies highlight the dual regulatory effects that 7,8-dihydroxyflavone exerts on bone formation and resorption.
    1. Medicine
    2. Microbiology and Infectious Disease

    Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time

    A Sarah Walker et al.
    Wide variation in cycle threshold (Ct) values from SARS-CoV-2 RT-PCR tests over calendar time offers the potential for their broader use in public testing programmes as an ‘early-warning’ system for shifts in infectious load and hence transmission.
    1. Epidemiology and Global Health
    2. Medicine

    Impact of COVID-19-related disruptions to measles, meningococcal A, and yellow fever vaccination in 10 countries

    Katy AM Gaythorpe et al.
    Routine and campaign vaccination disruption in 2020 may lead to measles outbreaks and yellow fever burden increases in some countries, but is unlikely to greatly increase meningococcal A burden.
    1. Medicine
    2. Neuroscience

    Two de novo GluN2B mutations affect multiple NMDAR-functions and instigate severe pediatric encephalopathy

    Shai Kellner et al.
    Two novel mutations in the GRIN2B gene reduce glutamate affinity by >1000-fold, reduce the receptors proton-sensitivity, and exert a dominant-negative effect over receptors in neurons.
    1. Medicine

    Restored TDCA and valine levels imitate the effects of bariatric surgery

    Markus Quante et al.
    Restored taurodeoxycholic acid and valine levels imitate the effects of bariatric surgery on weight loss and obesity-related disorders.