Browse our latest Medicine articles

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    1. Medicine
    2. Neuroscience

    Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality

    Angela Kim et al.
    Two non-overlapping neural circuits that involve the lamina terminalis and arcuate nucleus of hypothalamus independently drive feedforward anticipatory suppression and activation of vasopressin neurons by drinking and feeding, respectively.
    1. Medicine
    2. Neuroscience

    Vasopressin: Predicting changes in osmolality

    Zhe Yang et al.
    Two neural circuits control the release of vasopressin in response to eating and drinking before there are any detectable changes in blood water levels.
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    1. Biochemistry and Chemical Biology
    2. Medicine

    The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis

    Chunbo Zhang et al.
    A series of experiments at the molecular level reveal the underlying mechanism of how a gene activates liver glucose production to regulate the blood glucose metabolism in mice.
    1. Cell Biology
    2. Medicine

    Proposed therapy, developed in a Pcdh15-deficient mouse, for progressive loss of vision in human Usher syndrome

    Saumil Sethna et al.
    A preclinical study using exogenous retinoids in a novel Usher syndrome 1F mouse model reveals a possible therapy to treat mutant PCDH15-mediated visual dysfunction.
    1. Medicine
    2. Neuroscience

    Reporting and misreporting of sex differences in the biological sciences

    Yesenia Garcia-Sifuentes, Donna L Maney
    A review of studies in the life sciences shows that inappropriate statistical approaches may distort conclusions on sex differences.
    1. Medicine
    2. Neuroscience

    Statistics: Sex difference analyses under scrutiny

    Colby J Vorland
    A survey reveals that many researchers do not use appropriate statistical analyses to evaluate sex differences in biomedical research.
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    1. Developmental Biology
    2. Medicine

    β-Catenin-NF-κB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

    Shikai Hu et al.
    Ductular reaction often observed in chronic liver pathologies such as in cystic fibrosis could be due to disruption of a novel complex of β-catenin-NF-κB and CFTR in cholangiocytes, which leads to persistent nuclear translocation of p65 and NF-κB activation.
    1. Chromosomes and Gene Expression
    2. Medicine

    Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia

    Tamara Garrido-Gomez et al.
    The in vivo transcriptomic fingerprint encoding defective decidualization comprises 120 genes associated with an imbalance hormonal signaling in the decidual endometria of women who developed severe preeclampsia.