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    1. Medicine

    Magnesium isoglycyrrhizinate alleviates alcohol-associated liver disease through targeting HSD11B1

    Lu Xiao, Lu Li ... Jia Xiao
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Medicine
    2. Structural Biology and Molecular Biophysics

    Direct MRI of collagen

    Jason Daniel Van Schoor, Markus Weiger ... Klaas P Pruessmann
    The direct observation of collagen using magnetic resonance imaging is possible, presenting a new method to study the protein in vivo.
    1. Medicine

    Hyperactivated glycolysis drives spatially patterned Kupffer cell depletion in MASLD

    Jia He, Ran Li ... Zhao Shan
    Glycolytic activation directly drives Kupffer cell loss in early metabolic dysfunction-associated steatotic liver disease, highlighting a targetable metabolic vulnerability.
    1. Medicine
    2. Epidemiology and Global Health

    Determining fragility and robustness to missing data in binary outcome meta-analyses, illustrated with conflicting associations between vitamin D and cancer mortality

    David Robert Grimes
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Medicine

    Platelets promote acute liver injury via extracellular vesicles-mediated Aldolase A

    Ruoxue Yang, Jinghua Liu ... Zhao Shan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Medicine
    2. Neuroscience

    A non-human primate model of Amyotrophic Lateral Sclerosis

    Rachael HA Jones, Luciano Saieva ... Stuart N Baker
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Genetics and Genomics
    2. Medicine

    Point of View: Teaching early-career researchers how to respond to peer reviewers

    Eric Kalkhoven, Manon Kluijtmans
    Responding to reports from peer reviewers is a crucial part of scientific publishing, but early-career researchers are rarely taught about this process.
    1. Cell Biology
    2. Medicine

    Uncovering shared and tissue-specific molecular adaptations to intermittent fasting in liver, brain, and muscle

    Yibo Fan, Senuri De Silva ... Thiruma V Arumugam
    A multi-tissue proteomic atlas uncovers the shared and distinct molecular signatures of metabolic flexibility induced by intermittent fasting.
    1. Medicine
    2. Neuroscience

    Evaluating biomarkers and prediction models with E2P Simulator

    Povilas Karvelis, Daniel Felsky ... Andreea O Diaconescu
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Medicine

    Evaluating the applicability of replication success metrics in animal-to-human translation: A simulation study

    Carolyne Jie Huang, Samuel Pawel ... Rachel Heyard
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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