Infection experiments in ferrets reveal swine influenza viruses need their hemagglutinin antigen to become stabilized for transmissibility, adding a new property to consider when triaging field isolates for pandemic potential.
Surveillance strategies based on whole genome sequencing could help with the early identification and detection of new forms of drug-resistant gonorrhoea.
Tissue infection by an extracellular pathogen is recapitulated by encasing a bacterial colony within a droplet gel to allow immune cell attack, driving spatially-controlled microbial social behavior.
An ECF-type transporter serves as broad-spectrum heme iron scavenger and allows an opportunistic pathogen to use multiple eukaryotic hemoproteins to overcome nutritional iron-limitation.
Conformational flexibility in HIV-1 capsid, provided by cyclophilin A binding, facilitates evasion of capsid-targeting restriction factor MxB, while allowing sequence change to facilitate cytotoxic T-cell evasion.
The first lethal Junín virus challenge model in immunocompetent mice provides insight into New World mammarenavirus pathogenesis and will serve as a model for the development of much-needed therapeutic interventions.
