Browse our latest Microbiology and Infectious Disease articles

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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Transmission networks of SARS-CoV-2 in Coastal Kenya during the first two waves: A retrospective genomic study

    Charles N Agoti et al.
    Genomic analysis of initial SARS-CoV-2 waves in Kenya revealed Mombasa City as a key gateway for variants entering Coastal Kenya with onward inter-county transmission highlighting significance of surveillance in major cities for early warning of lineages entering local populations.
    1. Microbiology and Infectious Disease

    Host chitinase 3-like-1 is a universal therapeutic target for SARS-CoV-2 viral variants in COVID-19

    Suchitra Kamle et al.
    Intervention of CHI3L1 using anti-CHI3L1 monoclonal antibody or chitinase inhibitor kasugamycin blocks epithelial infection of various SARS-CoV2 variants, suggesting that CHI3L1 is a universal and effective therapeutic target of COVID-19 infection, including recent omicron variants.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

    Stefano G Giulieri et al.
    A large-scale analysis of Staphylococcus aureus within-host evolution based on a comprehensive catalogue of bacterial genetic variation reveals an excess of genome degradation signatures in infecting strains and new genetic loci of clinically relevant adaptation.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context

    Atanas Radkov et al.
    Distinct surfaces of an interbacterial competition cell wall toxin mediate interactions with different cellular binding partners, resulting in an inherent evolutionary trade-off across the toxin superfamily.
    1. Microbiology and Infectious Disease

    Metabolic arsenal of giant viruses: Host hijack or self-use?

    Djamal Brahim Belhaouari et al.
    Metabolic pathways found to date in giant virus raise the question if these viral enzymes provide some level of autonomy to viruses or if they are used to expand the host metabolism.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant Plasmodium falciparum

    Thiery Masserey et al.
    Models of malaria and treatment dynamics were combined with emulator-based global sensitivity analysis to elucidate the interplay between drug, biology, and epidemiological factors on the evolution of resistance to malaria treatments, including artemisinin.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV

    Tongcui Ma et al.
    Glycans are remodeled by HIV and are determinants of CD4+ T cell susceptibility to HIV infection.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Controlling SARS-CoV-2 in schools using repetitive testing strategies

    Andrea Torneri et al.
    In primary schools, where vaccination coverage can be low, a repetitive testing strategy reduces SARS-CoV-2 infections while keeping classes and schools open, as such limiting infection transmissions and absenteeism.
    1. Microbiology and Infectious Disease

    Heavy isotope labeling and mass spectrometry reveal unexpected remodeling of bacterial cell wall expansion in response to drugs

    Heiner Atze et al.
    Labeling with 13C and 15N in the absence of metabolic engineering enabled the exploration of peptidoglycan metabolism at a very fine level of detail based on kinetic characterization of isotopologues predicted to occur according to known recycling and biosynthesis pathways.