Browse our latest Microbiology and Infectious Disease articles

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    1. Cell Biology
    2. Microbiology and Infectious Disease

    Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation

    Pierre Lapaquette et al.
    Shigella infection induces a calpain-mediated loss of SUMO conjugates that promotes bacterial entry.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Phenotype inference in an Escherichia coli strain panel

    Marco Galardini et al.
    The mechanistic impact of genetic variants can be combined with previous knowledge on gene function to deliver conditional growth predictions and pave the way for personalized genetic interventions.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis

    Zhaowei Wang et al.
    A picorna-like virus promotes the accumulation of caspase-cleaved drosophila inhibitor of apoptosis 1 by inducing the degradation of NTAN1, a key N-end rule degradation pathway component, leading to apoptosis inhibition and viral replication enhancement.
    1. Microbiology and Infectious Disease

    Severe infections emerge from commensal bacteria by adaptive evolution

    Bernadette C Young et al.
    Life-threatening S. aureus infections emerge from commensal nose bacteria in association with repeatable adaptive evolution.
    1. Microbiology and Infectious Disease

    An Aedes aegypti-associated fungus increases susceptibility to dengue virus by modulating gut trypsin activity

    Yesseinia I Angleró-Rodríguez et al.
    Talaromyces (Tsp_PR) fungus render Aedes aegypti mosquitoes more susceptible to dengue virus infection through secreted molecules that impair midgut digestive enzyme transcription and activity.
    1. Developmental Biology and Stem Cells
    2. Microbiology and Infectious Disease

    Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium

    David R Hill et al.
    Contact with bacteria and subsequent hypoxia promotes functional maturation of the immature gastrointestinal tract.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Coupling chemosensory array formation and localization

    Alejandra Alvarado et al.
    Formation and cell pole-localization of chemotactic signaling-arrays is a coupled process mediated by ParP, which drives localized array-assembly and regulates the localization-dynamics of its network constituents.
    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Stochastic variation in the initial phase of bacterial infection predicts the probability of survival in D. melanogaster

    David Duneau et al.
    An analysis of within-host bacterial proliferation reveals that minor "stochastic" variation in the ability of the innate immune response to control bacterial growth early on can result in either survival or death of the host.
    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Host Defense: Are we immune by chance?

    Andrea L Graham, Ann T Tate
    The sooner the immune system launches, the greater the chances the host has of survival.
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    1. Microbiology and Infectious Disease

    Structural basis of host recognition and biofilm formation by Salmonella Saf pili

    Longhui Zeng et al.
    SafDAA-SafDAA structure and functional characterizations reveal a pili-mediated inter-cellular oligomerization mechanism for bacterial aggregation and biofilm formation in Salmonella enterica.