Browse our latest Neuroscience articles

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    1. Neuroscience

    Ultrafast simulation of large-scale neocortical microcircuitry with biophysically realistic neurons

    Viktor J Oláh, Nigel P Pedersen, Matthew JM Rowan
    Artificial neural networks can faithfully recapitulate realistic neuronal behavior with dramatically accelerated simulation runtimes, empowering accessible large-scale realistic network simulations.
    1. Neuroscience

    Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus

    Rachana Deven Somaiya, Katelyn Stebbins ... Michael A Fox
    Retinal ganglion cell axons release the morphogen sonic hedgehog which signals through astrocytes to induce the migration of inhibitory interneurons into the developing visual thalamus.
    1. Neuroscience

    Contextual effects in sensorimotor adaptation adhere to associative learning rules

    Guy Avraham, Jordan A Taylor ... Samuel D McDougle
    Core associative learning phenomena that are observed in studies of eyeblink conditioning are also observed in sensorimotor adaptation, pointing to a common framework for these distinct cerebellar-dependent motor learning processes.
    1. Developmental Biology
    2. Neuroscience

    Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature

    Francesco A Servello, Rute Fernandes ... Javier Apfeld
    C. elegans nematodes can assess faithfully the threat that H2O2 poses by coupling the induction of their H2O2 defenses to the perception of high temperature—an inherent enhancer of the reactivity of H2O2.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Tissue-specific mitochondrial HIGD1C promotes oxygen sensitivity in carotid body chemoreceptors

    Alba Timón-Gómez, Alexandra L Scharr ... Andy J Chang
    An atypical configuration of mitochondrial electron transport chain proteins may underlie the exquisite sensitivity of the carotid body to small decreases in oxygen availability.
    1. Developmental Biology
    2. Neuroscience

    A dynamic and expandable digital 3D-atlas maker for monitoring the temporal changes in tissue growth during hindbrain morphogenesis

    Matthias Blanc, Giovanni Dalmasso ... Cristina Pujades
    The digital 3D-atlas maker will help ascribing neuronal birthdate and neuronal differentiation times upon gene disruption in zebrafish avatars for human diseases, and will allow the integration of the information generated in other laboratories.
    1. Neuroscience

    An inhibitory circuit from central amygdala to zona incerta drives pain-related behaviors in mice

    Sudhuman Singh, Torri D Wilson ... Yarimar Carrasquillo
    Inhibition of the zona incerta by central amygdala neurons expressing PKCδ contributes to injury-induced peripheral hypersensitivity in a mouse model of neuropathic pain.
    1. Computational and Systems Biology
    2. Neuroscience

    The interpretation of computational model parameters depends on the context

    Maria Katharina Eckstein, Sarah L Master ... Anne GE Collins
    Context factors such as experimental task and model parameterization can significantly impact modeling results, such that across tasks, the same participants show different fitted parameter values, and parameters capture different cognitive processes across tasks.
    1. Neuroscience

    Recalibrating vision-for-action requires years after sight restoration from congenital cataracts

    Irene Senna, Sophia Piller ... Marc O Ernst
    Late cataract-treated individuals learn to recalibrate vision for action in the months to years after sight restoration surgery, demonstrating that this ability can develop even in the absence of early pattern vision.
    1. Neuroscience

    Vocalization categorization behavior explained by a feature-based auditory categorization model

    Manaswini Kar, Marianny Pernia ... Srivatsun Sadagopan
    A theoretical model that uses maximally informative spectrotemporal features to classify vocalizations, trained solely on natural guinea pig vocalizations, predicts guinea pig behavioral performance in classifying natural as well as spectrotemporally manipulated vocalizations.