Browse our latest Neuroscience articles

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    1. Neuroscience

    Activity-dependent regulation of mitochondrial motility in developing cortical dendrites

    Catia AP Silva, Annik Yalnizyan-Carson ... Christian Lohmann
    Naturally occurring activity in the developing brain regulates mitochondrial motility such that mitochondria stop at active synapses, which is probably a fundamental process in brain wiring.
    1. Neuroscience

    Separable neural signatures of confidence during perceptual decisions

    Tarryn Balsdon, Pascal Mamassian, Valentin Wyart
    Neural processes for perception and confidence can be separated thanks to computational electroencephalography, thus revealing a neural circuit specific to metacognition.
    1. Neuroscience

    Distributed functions of prefrontal and parietal cortices during sequential categorical decisions

    Yang Zhou, Matthew C Rosen ... David J Freedman
    Prefrontal cortex plays a leading role in sequential decisions compared to posterior parietal cortex and relies on nonlinear integration of sensory and mnemonic information for decision formation.
    1. Neuroscience

    The severity of microstrokes depends on local vascular topology and baseline perfusion

    Franca Schmid, Giulia Conti ... Bruno Weber
    The number of inflows and outflows at the occluded capillary governs the local flow reduction, and the different topological configurations are probably designed for distinct functional tasks.
    1. Neuroscience

    Motor planning under uncertainty

    Laith Alhussein, Maurice A Smith
    New evidence shows that when there is uncertainty about an action's goal the motor system creates a single action plan that optimizes task performance rather than averaging multiple potential plans.
    1. Neuroscience

    Reexamination of N-terminal domains of syntaxin-1 in vesicle fusion from central murine synapses

    Gülçin Vardar, Andrea Salazar-Lázaro ... Christian Rosenmund
    A mutant rescue approach in STX1-null autaptic neurons provides definitive answers and opens up new questions into a controversial matter of syntaxin-1's binding to Munc18-1 through its N-peptide and its function in neurotransmission.
    1. Neuroscience

    Scanned optogenetic control of mammalian somatosensory input to map input-specific behavioral outputs

    Ara Schorscher-Petcu, Flóra Takács, Liam E Browne
    A system to generate ‘remote touch’ in freely behaving mice can be utilized to map behavior caused by precise somatosensory inputs.
    1. Neuroscience

    Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans

    Trygve E Bakken, Cindy TJ van Velthoven ... Bosiljka Tasic
    Transcriptomic differences between relay neurons in the mature mammalian dLGN are subtle relative to striking differences in morphology and cortical projection targets.
    1. Neuroscience

    Systematic morphological and morphometric analysis of identified olfactory receptor neurons in Drosophila melanogaster

    Cesar Nava Gonzales, Quintyn McKaughan ... Chih-Ying Su
    A morphological characterization of Drosophila olfactory receptor neurons—conducted systematically at nanoscale resolution—yields an extensive morphometric dataset, identifies novel features of olfactory sensilla, and raises intriguing questions for how the size and shape of sensory neurons influence their function.
    1. Cell Biology
    2. Neuroscience

    TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons

    Ki Bum Um, Suyun Hahn ... Myoung Kyu Park
    The non-selective Na+ leak channel (NALCN) and the transient receptor potential 3 channel (TRPC3) cooperate in driving pacemaking in substantia nigra dopaminergic neurons.