Browse our latest Neuroscience articles

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    1. Genetics and Genomics
    2. Neuroscience

    A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons

    Gha-Hyun J Kim, Han Mo ... Su Guo
    In vivo dopamine neuron imaging-based neuroprotective small molecule screen in larval zebrafish and mechanistic investigation using conditional CRISPR knockout and cell-type-specific RNA-seq analysis, coupled with cross-species analyses including human clinical data interrogation, uncover potential disease-modifying therapeutics for Parkinson's disease (PD).
    1. Neuroscience

    DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels

    James P Bohnslav, Nivanthika K Wimalasena ... Christopher D Harvey
    DeepEthogram automatically classifies animal behavior videos into researcher-defined behaviors of interest, saving researcher time and enabling more detailed downstream analysis of behavior.
    1. Neuroscience

    Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression

    Anita E Autry, Zheng Wu ... Catherine Dulac
    Genetic and functional manipulations uncover urocortin-3-expressing neurons in the perifornical area of the hypothalamus as a dedicated circuit component for the expression of infant-directed neglect and aggression in mice.
    1. Neuroscience

    Sleeping at the switch

    Maude Bouchard, Jean-Marc Lina ... Julie Carrier
    Slow and fast switcher slow waves in human sleep show distinct EEG connectivity patterns and homeostatic regulation as well as changes during aging.
    1. Neuroscience

    A quadratic model captures the human V1 response to variations in chromatic direction and contrast

    Michael A Barnett, Geoffrey K Aguirre, David Brainard
    A quantitative forward model captures fMRI responses to chromatic stimuli in human primary visual cortex and quantifies how chromatic sensitivity changes with eccentricity.
    1. Neuroscience

    Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex

    Eric Kenji Lee, Hymavathy Balasubramanian ... Chandramouli Chandrasekaran
    WaveMAP is a novel approach that combines nonlinear dimensionality reduction with graph clustering on extracellular waveforms to reveal previously obscured cell type diversity in monkey cortex.
    1. Neuroscience

    Developmental change in prefrontal cortex recruitment supports the emergence of value-guided memory

    Kate Nussenbaum, Catherine A Hartley
    The use of prior experience to adaptively prioritize information in memory increases from childhood to adulthood and engages corticostriatal circuitry.
    1. Neuroscience

    Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons

    Jason D Vevea, Grant F Kusick ... Edwin R Chapman
    Synaptotagmin 7 is asymmetrically localized to the axonal plasma membrane through γ-secretase processing to promote vesicle docking during short-term synaptic plasticity in mouse hippocampal neurons.
    1. Developmental Biology
    2. Neuroscience

    Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons

    Meike E van der Heijden, Elizabeth P Lackey ... Roy V Sillitoe
    Intersectional genetics show that excitatory neurons are essential for the functional and anatomical maturation of cerebellar circuits in mice.
    1. Developmental Biology
    2. Neuroscience

    Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping

    Baruch Haimson, Yoav Hadas ... Avihu Klar
    Spinal dI2 interneurons relay peripheral and intraspinal feedback to premotor networks in the spinal cord and the cerebellum to ensure the stability of bipedal stepping.