Following chronic hyperactivation using chemogenetics, vulnerable substantia nigra dopamine neurons display progressive degeneration unlike neighboring ventral tegmental area dopamine neurons.
Johannes Jacobus Fahrenfort, Philippa A Johnson ... Simon van Gaal
This response counters arguments given in a commentary by Sandberg and Overgaard, 2025 regarding an article in eLife about criterion confounds in neural measures of consciousness based on subjective measures by Fahrenfort et al, 2025.
A versatile computational framework realistically simulates fluorescence lifetime data in biological systems, enhancing rigor by quantifying signal variance and identifying limitations, and enabling innovations such as multiplexed dynamic biosensor imaging.