Ion channel voltage-dependence alterations can shape intrinsic homeostatic plasticity, even if operating faster than other intrinsic regulatory processes—where timescale separation would suggest its influence should be negligible.
Full-length, autoinhibited LRRK2 assembles into distinct, shorter microtubule-bound filaments via a previously unobserved N-terminal repeat interface, revealing new structural states with potential therapeutic implications.
Laura J Smithson, Juliana L Zang ... Catherine A Collins
Transcriptional responses to axonal damage are required for circuit repair, but these responses are restrained in injuries that leave spared axonal branches.
