Browse our latest Neuroscience articles

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    1. Neuroscience

    Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS

    María de Lourdes Martínez-Silva, Rebecca D Imhoff-Manuel ... Marin Manuel
    The most vulnerable motor units lose a fundamental firing property before the denervation of their muscle fibers in ALS mice, changing our view of the role of excitability in neurodegeneration.
    1. Neuroscience

    Amyotrophic Lateral Sclerosis: Marking the differences in motoneurons

    Simon A Sharples, Patrick J Whelan
    A subgroup of the neurons that control muscles becomes less excitable shortly before the symptoms of ALS develop.
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    Insight
    1. Neuroscience

    VEGF signaling regulates the fate of obstructed capillaries in mouse cortex

    Patrick Reeson, Kevin Choi, Craig E Brown
    Mapping the fate of clogged brain capillaries reveals that VEGF signaling plays a critical role in dictating whether capillaries regain blood flow and persist or are pruned from the vascular tree.
    1. Developmental Biology
    2. Neuroscience

    A transcription factor collective defines the HSN serotonergic neuron regulatory landscape

    Carla Lloret-Fernández, Miren Maicas ... Nuria Flames
    The collective action of six transcription factors selects and activates the regulatory regions of the HSN serotonergic neuron effector genes constituting a signature that can be used for the novo identification of HSN expressed genes.
    1. Neuroscience

    Acute intermittent hypoxia enhances corticospinal synaptic plasticity in humans

    Lasse Christiansen, MA Urbin ... Monica A Perez
    Acute intermittent hypoxia is a noninvasive approach that enhances corticospinal function in humans, likely through alterations in corticospinal-motoneuronal synaptic transmission.
    1. Computational and Systems Biology
    2. Neuroscience

    Antagonism in olfactory receptor neurons and its implications for the perception of odor mixtures

    Gautam Reddy, Joseph D Zak ... Venkatesh N Murthy
    Computational and theoretical analyses offer novel and unexpected insight into how complex, naturally occurring odor mixtures are parsed and normalized at the very first stage of olfaction.
    1. Neuroscience

    A zebrafish and mouse model for selective pruritus via direct activation of TRPA1

    Kali Esancy, Logan Condon ... Ajay Dhaka
    A pain-relaying ion channel on a hypersensitive population of sensory neurons can instead elicit sensations of itch in both fish and mice when directly activated, providing a novel model of itch transduction.
    1. Neuroscience

    Adult-born neurons facilitate olfactory bulb pattern separation during task engagement

    Wankun L Li, Monica W Chu ... Takaki Komiyama
    Adult-born neurons in the olfactory bulb allow state-dependent pattern separation of representations of similar odorants.
    1. Neuroscience

    Structural and functional properties of a probabilistic model of neuronal connectivity in a simple locomotor network

    Andrea Ferrario, Robert Merrison-Hort ... Roman Borisyuk
    A new probabilistic model of connectivity reveals the structural and functional properties of the neural networks controlling locomotion in many individual tadpoles.
    1. Neuroscience

    Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior

    Chang-Hui Tsao, Chien-Chun Chen ... Suewei Lin
    Mushroom bodies are a hunger and satiety integrative center that controls food-seeking behavior in Drosophila..