Browse our latest Neuroscience articles

Page 498 of 644
    1. Neuroscience

    Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons

    Lei Xiao, Michael F Priest, Yevgenia Kozorovitskiy
    Oxytocin, a peptide linked to the processing of socially meaningful stimuli, modulates excitatory synaptic transmission in dopaminergic neurons of ventral tegmental area via retrograde endocannabinoid signaling, acting as a pathway-specific temporal filter for synaptic inputs.
    1. Neuroscience

    Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum

    Tim James Viney, Minas Salib ... Peter Somogyi
    GABAergic parvalbumin-expressing 'orchid cells' of the medial septum selectively target GABAergic neurons in connected extra-hippocampal areas of the mouse, providing rhythmically bursting inhibitory input at the peak of hippocampal 5-12 Hz theta oscillatory cycles.
    1. Neuroscience

    Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity

    Amy E Pohodich, Hari Yalamanchili ... Huda Y Zoghbi
    Forniceal deep brain stimulation is a promising treatment for several neuropsychiatric disorders as it upregulates synaptic and neurogenesis-associated genes, normalizes genes misregulated in Rett syndrome mice, and regulates genes altered in intellectual disability and major depression.
    1. Neuroscience

    Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility

    Valerie A Larson, Yevgeniya Mironova ... Dwight E Bergles
    Oligodendrocytes in white matter use Kir4.1 inwardly rectifying potassium channels to prevent extracellular potassium accumulation, enabling neurons to sustain repetitive firing and limiting the initiation of seizures.
    1. Neuroscience

    Endogenous opioids in the nucleus accumbens promote approach to high-fat food in the absence of caloric need

    Kevin Caref, Saleem M Nicola
    Activation of mu-opioid receptors in the nucleus accumbens by their endogenous ligands promotes consumption of high-fat food in sated but not hungry rats, via enhancement of a neural signal that promotes cued approach behavior.
    1. Neuroscience

    A transformation from temporal to ensemble coding in a model of piriform cortex

    Merav Stern, Kevin A Bolding ... Kevin M Franks
    A spiking network model that examines the transformation of odor information from olfactory bulb to piriform cortex demonstrates how intrinsic cortical circuitry preserves representations of odor identity across odorant concentrations.
    1. Neuroscience

    First spikes in visual cortex enable perceptual discrimination

    Arbora Resulaj, Sarah Ruediger ... Massimo Scanziani
    A brief time window of visually evoked activity in mouse primary visual cortex is sufficient for perceptual discrimination.
    1. Neuroscience

    Control of voluntary and optogenetically perturbed locomotion by spike rate and timing of neurons of the mouse cerebellar nuclei

    Rashmi Sarnaik, Indira M Raman
    Stride-related modulated firing by neurons of the cerebellar nuclei is required for smooth execution of practiced locomotion and persists more easily with synchronous than asynchronous Purkinje-mediated inhibition.
    1. Medicine
    2. Neuroscience

    Neurovascular sequestration in paediatric P. falciparum malaria is visible clinically in the retina

    Valentina Barrera, Ian James Callum MacCormick ... Simon Peter Harding
    Clinical, clinicopathological and image data from Malawian children shows that sequestration in P. falciparum cerebral malaria is visible clinically in the eye as orange retinal vessels and is strongly associated with death.
    1. Neuroscience

    Differential 3’ processing of specific transcripts expands regulatory and protein diversity across neuronal cell types

    Saša Jereb, Hun-Way Hwang ... Robert B Darnell
    Differential expression of 3'UTR isoforms expands regulatory and protein diversity in cerebellar Purkinje and granule cells and during granule cell development.