Browse our latest Neuroscience articles

Page 55 of 619
    1. Neuroscience

    An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

    Pratibha Thakur, Martin Lackinger ... Joseph A Gogos
    Targeting EMC10 restores neuronal function in 22q11.2DS patient-derived neurons and reverses cognitive deficits in adult mice, highlighting its potential as a therapeutic strategy for mitigating disease-related cognitive impairments.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers

    Robert G Stewart, Matthew James Marquis ... Jon T Sack
    Drugs are identified that unmask molecular origins of certain neuronal potassium currents, enabling functional analysis of previously indistinguishable potassium channel subtypes.
    1. Developmental Biology
    2. Neuroscience

    Commissureless acts as a substrate adapter in a conserved Nedd4 E3 ubiquitin ligase pathway to promote axon growth across the midline

    Kelly G Sullivan, Greg J Bashaw
    Commissureless works with the Nedd4 E3 ubiquitin ligase to transiently degrade the Robo1 receptor to allow commissural axons to cross the midline.
    Version of Record
    Research Article
    • Fundamental
    • Compelling
    • Convincing
    1. Neuroscience

    Network segregation is associated with processing speed in the cognitively healthy oldest-old

    Sara A Nolin, Mary E Faulkner ... Kristina M Visscher
    Greater differentiation of brain networks is a hallmark of good cognitive functioning among individuals who have avoided neurodegenerative disease and live longer than a typical human lifespan.
    1. Neuroscience

    Subcortical correlates of consciousness with human single neuron recordings

    Michael Pereira, Nathan Faivre ... Olaf Blanke
    Subcortical brain structures contain neurons encoding subjective reports of stimulus detection in human participants, suggesting a role for conscious perception.
    1. Neuroscience

    Locus coeruleus modulation of single-cell representation and population dynamics in the mouse prefrontal cortex during attentional switching

    Marco Nigro, Lucas Silva Tortorelli ... Hongdian Yang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Spatial periodicity in grid cell firing is explained by a neural sequence code of 2-D trajectories

    Rebecca RG, Giorgio A Ascoli ... Holger Dannenberg
    The characteristic hexagonal firing pattern of grid cells emerges as the most parsimonious solution to a trajectory code by cell sequences.
    1. Cell Biology
    2. Neuroscience

    Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival

    Moloy T Goswami, Eric Weh ... Thomas J Wubben
    For the first time, mouse models reveal the metabolic dependency of photoreceptors on glutamine catabolism in vivo and further demonstrate the flexibility of photoreceptors to utilize fuel sources beyond glucose.
    1. Cell Biology
    2. Neuroscience

    Vision: A pathway to sight

    Katherine J Wert
    The breakdown of glutamine is an important metabolic pathway for the health and survival of rod photoreceptors within the retina.
    Version of Record
    Insight