Marta Pallotto, Paul V Watkins ... Kevin L Briggman
Automated segmentation of neurons and identification of synapses in electron micrographs is significantly improved by using simple modifications to chemical fixation protocols that preserve extracellular space in the brain.
Computational modeling suggests that feedback between striatal cholinergic neurons and spiny neurons dynamically adjusts learning rates to optimize behavior in a variable world.
The small GTPase Arf6 plays a role in setting the size of the readily releasable pool of synaptic vesicles and in the definition of the recycling route for endocytosed vesicles.
Caspar M Schwiedrzik, Benjamin Bernstein, Lucia Melloni
Looking at visual motion affects perception of nonsymbolic numerosity in a direction-specific way, indicating that motion and number are computed by the same neurons.
Whenever monkeys are required to choose between multiple options, neural responses indicate that they first select the desired outcome and then use this information to guide their actions.
Aberrant ERK/MAPK signaling in cortical pyramidal neurons leads to selective disruption of layer 5 circuit development and generalized changes in neuronal excitability.
Neil C Rabinowitz, Robbe L Goris ... Eero P Simoncelli
Populations of neurons in the macaque visual cortex are subject to shared fluctuations in gain; these signals exhibit anatomical and functional structure, and their variability is diminished under attention.
Tomas Fanutza, Dolores Del Prete ... Luciano D’Adamio
A naturally occurring intracellular peptide, derived by processing the Alzheimer's protein APP, reduces synaptic transmission by acting as a dominant negative of APP.
