Functional connectivity mapping reveals sparse, specific, and largely complementary cortical innervation of individual striatal medium spiny neurons within overlapping and loosely topographical projections from the barrel cortex.
Rapamycin, competing with other rapalogs, activates TRPM8 via directly binding to a novel binding site, which results in providing new insights into the mechanisms of TRPM8 activation.
Ecem Altan, Catherine A Morgan ... D Samuel Schwarzkopf
Modulations in population receptive field size induced by spatial frequency adaptation reveal a direct link between spatial tuning in the visual cortex and spatial frequency selectivity of neuronal populations.
LINE-1-encoded ORF1p is widely expressed in neurons, increases with age, and engages neuron-specific protein partners, revealing a dynamic role for retrotransposons in brain physiology and aging.
CryoCLEM-guided cryoET of Psd95-GFP knockin mouse tissue and ultra-fresh synaptonerosomes indicate that the postsynaptic density is a not a conserved feature of glutamatergic synapses in the mouse brain.
Rewiring the command neurons in the tactile circuit is sufficient to change the behavioral strategy of a whole animal, implying a 'plug-and-play' flexibility in sensorimotor circuits.
