Rab10 and Rab4 bidirectionally regulate AMPA receptor trafficking and spine structural plasticity during long-term potentiation by exhibiting opposing and temporally distinct activity patterns in stimulated dendritic spines.
Christopher M Kim, Carson C Chow, Bruno B Averbeck
Neural activity during reversal learning encodes decision-related evidence integrated across trials and shows substantial dynamics during each trial, suggesting an extension of the line attractor model that incorporates non-stationary dynamics.
To parse foreground and background sounds, the auditory cortex of humans and ferrets share a similar hierarchical organization, but the underlying computational mechanisms are fundamentally different.
Veronica H Ryan, Sydney Lawton ... Michael Emmerson Ward
Protein, but not mRNA, levels of neurodegenerative disease-associated protein TDP-43 are decreased upon knockdown of BORC, a complex that is required for the anterograde transport of lysosomes.
Justin M Campbell, Rhiannon L Cowan ... Jon Timothy Willie
Firing rate analyses revealed neurons throughout the hippocampus, amygdala, orbitofrontal cortex, and anterior cingulate cortex in humans that exhibited heterogeneous responses to intracranial theta burst stimulation of the human brain.
Fully autonomous home-cage training system HABITS enables mice to learn complex cognitive behaviors without human intervention, expanding behavioral paradigms and optimizing training efficiency through machine teaching algorithms.
