Mice can generate a cognitive map of an environment based on self-motion signals when there is a fixed association between their starting point and the location of their goal.
The amphipathic helix at the C-terminus of Complexin II prevents premature secretion, whereas its N-terminal domain regulates mechanisms which are governed by the forward rate of Ca2+ binding to Synaptotagmin I.
Juan Carlos Boffi, Brice Bathellier ... Robert Prevedel
Bespoke volumetric calcium imaging, validated with neuropixels recordings, evidence a population code for sound azimuth at the dorsal cortex of the inferior colliculus, with a contribution of noise correlations.
Stimulation of the ipsilateral motor cortex after spinal cord injury activates bilateral motor synergy and restores hindlimb movement, advancing neuroprosthetic strategies for motor recovery.
Katie Morris, Edita Bulovaite ... Mathew H Horrocks
PSD95 supercomplexes maintain long-term stability through gradual subunit replacement, with the slowest turnover in cortical synapses associated with memory storage.
John P Grogan, Matthias Raemaekers ... Sanjay G Manohar
Muscarinic antagonism is causally involved in motivation and incentivisation in healthy human participants, partially mediated via preparatory neural signatures, with implications for cholinergic treatment of Parkinson's disease.
Samyogita Hardikar, Bronte Mckeown ... Jonathan Smallwood
Interactions between attention systems and the default mode network are linked to individual differences in trait and state-level experience and cognition.
The results of central nervous regulation in mice provide a new neural circuit and receptor regulatory mechanisms for the recovery of consciousness after midazolam administration.
