NR4A is a broadly conserved transcription factor that is required for concordance of patterning information and anatomy at both ends of the planarian anterior-posterior axis.
Julian Stolper, Elizabeth Mayela Ambrosio ... Lazaro Centanin
The fish gill, an ever-growing organ with fast turnover rate, displays dedicated stem-cell populations for growth and homeostasis that are interchangeable upon external challenges.
An unbiased RNAseq based strategy to identify targetable pathways and a streamlined lentiviral system provide a state of the art advance on direct fibroblast to neuron conversion.
Mohsen Afshar Bakooshli, Ethan S Lippmann ... Penney M Gilbert
Human skeletal muscle progenitors and motor neurons self-organize in three-dimensional co-culture to form functional neuromuscular junctions that developmentally mature from the embryonic to the adult state.
Fusion of muscle progenitors drives continuous myonuclear accretion during exercise and impacts various adaptations in skeletal muscle including response to injury and hypertrophy.
Mirko Francesconi, Bruno Di Stefano ... Thomas Graf
Variation in efficiency, speed and path during transdifferentiation and reprogramming originates from two pre-B cell subpopulations with reciprocal propensity towards each fate conversion.