Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Screening identifies small molecules that enhance the maturation of human pluripotent stem cell-derived myotubes

    Sridhar Selvaraj, Ricardo Mondragon-Gonzalez ... Rita CR Perlingeiro
    Treatment of human pluripotent stem cell-derived myotubes with a cocktail of small molecules induces their maturation, as shown by gene expression, biochemical and functional assays.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Regeneration: Lymphatic vessels help mend broken hearts

    Catherine Pfefferli, Anna Jaźwińska
    Experiments on zebrafish show that the regeneration of the heart after an injury depends on lymphatic vessels.
    Version of Record
    Insight
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells

    Isabelle Maria Blomfield, Brenda Rocamonde ... Noelia Urbán
    Genetic and protein analyses in vitro and in vivo identifies Id4 as a novel regulator of stem cell quiescence in the adult hippocampus.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Self-assembling manifolds in single-cell RNA sequencing data

    Alexander J Tarashansky, Yuan Xue ... Bo Wang
    An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A distinct transition from cell growth to physiological homeostasis in the tendon

    Mor Grinstein, Heather L Dingwall ... Jenna Lauren Galloway
    Mitotic labeling defines a change in cell division kinetics from growth to homeostasis and identifies slowly cycling cells in the adult tendon.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

    Kevin Achberger, Christopher Probst ... Peter Loskill
    A microphysiological system (retina-on-a-chip) shows the potential to promote drug development and provide new insights into the underlying pathology of retinal diseases.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Tissue Engineering: Building a better model of the retina

    Milica Radisic
    Researchers have combined organ-on-a-chip engineering with the benefits of organoids to make improved models of the human retina.
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    Insight
    1. Stem Cells and Regenerative Medicine

    Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle

    Sumiaki Fukuda, Akihiro Kaneshige ... So-ichiro Fukada
    Proliferating muscle stem cells in overloaded muscle require special molecular mechanisms that differ from well-known myogenic differentiation model.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Human perivascular stem cell-derived extracellular vesicles mediate bone repair

    Jiajia Xu, Yiyun Wang ... Aaron Watkins James
    Perivascular extracellular vesicles induce bone repair, and do so via tetraspanin binding to recipient skeletal progenitor cells.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation

    Jelle van den Ameele, Andrea H Brand
    Mitochondrial dysfunction in neural stem cells and brain tumour cells decreases proliferation and affects the generation of neuronal diversity and tumour heterogeneity.