Browse our latest Structural Biology and Molecular Biophysics articles

A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.

The architectures of human PIEZO1 and its slow-inactivating channelopathy mutants with or without its auxiliary subunit MDFIC reveal the inactivation mechanism of PIEZO channels.

The cryo-EM structures of a pentameric ligand-gated ion channel in liposomes, an environment that supports ion channel function, are different than structures in lipid nanodiscs.

Customized AlphaFold-based modeling of distinct functional states of the hERG channel, a major drug anti-target, significantly improves drug affinity predictions, enhancing cardiac safety screening for arrhythmia risk.

Polyphosphate, a universal stress response regulator, binds distinctively to different starting ensembles of the same protein leading to either condensates or aggregates that in turn can solubilize or further aggregate, showcasing their ability to finely control the assembly process.

Exponential nucleic acid replication can occur isothermally in a prebiotically plausible setting that accumulates and simultaneously separates the strands of nucleic acids through evaporation-driven flows at the gas–water interface.