Browse our latest Structural Biology and Molecular Biophysics articles

Optical tweezers are used to gain mechanistic insight in the mechanism of inhibition of three distinct compounds being developed as antibiotics against Mycobacterium tuberculosis.

Conserved sequence motifs within intrinsically disordered protein regions act as evolutionary units that support phase separation and membraneless organelle formation.

A sequence-based method, DIRseq, has been developed to predict drug-interacting residues of intrinsically disordered proteins.

CryoCLEM-guided cryoET of Psd95-GFP knockin mouse tissue and ultra-fresh synaptonerosomes indicate that the postsynaptic density is a not a conserved feature of glutamatergic synapses in the mouse brain.

A combination of cryogenic electron microscopy and molecular simulations has been used to study the structure and dynamics of an enzyme called ACE.

Structural and computational approaches uncover the molecular basis for dimerization, open-closed conformational transitions, and the dynamic behavior of the human angiotensin-I converting enzyme dimer.

Piezo proteins induce a curved protein-membrane nanodome with an excess area of about 40 nm² in tensionless membranes and resist tension-induced flattening with a force constant of about 60 pN/nm.