Browse our latest Structural Biology and Molecular Biophysics articles

Hydration modulates aromatic interactions, explaining why Tyr is a stronger sticker than Phe in aqueous environments like protein condensates but not in the cores of folded proteins.

Cryo-EM and electrophysiology reveal the mechanism of SK2 channel modulation by the bee toxin apamin and small molecules, providing insights that enable the rational design of targeted SK2 channel therapeutics.

The path of potassium through an ATP-dependent membrane pump is elucidated with a high-resolution structure within a lipid bilayer together with mutational analysis at key points along this pathway.

Distinct asymmetric states in membrane-bound pyrophosphatases reveal how inhibitors block their activity and inform drug development.

Single-molecule imaging uncovers how distinct membrane-binding motifs and the intrinsically disordered C-terminal domain control RNase E’s membrane association and diffusion, linking structural divergence to RNA-processing dynamics in bacteria.

New psychoactive substances activate cannabinoid receptors using distinct ligand-receptor interactions.

Full-length, autoinhibited LRRK2 assembles into distinct, shorter microtubule-bound filaments via a previously unobserved N-terminal repeat interface, revealing new structural states with potential therapeutic implications.