Browse our latest Structural Biology and Molecular Biophysics articles

The crystal structure of Sld3CBD-Cdc45 shows its intermolecular interactions, and subsequent Sld3CBD-CMG model construction and binding assays enable a proposal for the mechanism of Cdc45 recruitment and Sld3 release.

The cryptic pocket is critical for one of the VP35 protein's functions and therefore is likely under selective pressure.

Environmental chloride ions act as essential counterions that enable coral opsins to respond to visible light, and the polar residue Glu292 plays a critical role in chloride binding.

The cryoEM structure of a RAD51 displacement loop reveals the molecular mechanism of the strand-exchange reaction at the centre of eukaryotic homologous recombination.

Cryogenic electron microscopy has been used to determine the detailed structure of an intermediate state called a “D-loop” that forms when strands of DNA are exchanged during homologous recombination.

Time-resolved fluorescence resonance energy transfer reveals conformational energetics of a bacterial cyclic nucleotide-gated ion channel.

Motile Enterobacteriaceae override chemorepulsion from the microbiota metabolite indole in favor of nutrient attraction, challenging the idea that indole taxis protects the host against intestinal infection.

The majority of TMEM16 lipid scrambling occurs in the open groove associated with Ca²⁺ activation, but limited scrambling also occurs in the dimer interface independent of Ca²⁺.