Browse our latest Structural Biology and Molecular Biophysics articles

Membrane geometry switches protein condensate organization of postsynaptic density proteins by reducing crowding effects while maintaining specific binding, allowing targeted interactions to dominate over size-based exclusion.

Promoting FtsZ toroidal polymer formation by ZapD offers new insights into stabilizing the bacterial division ring.

p53 isoforms induce cellular stress based on their only partially folded states.

Grafting surface loops containing antibody epitopes of a poorly expressed flu neuraminidase protein onto a high-expressing, stable scaffold improves its production and stability for vaccine development.

Ten-microsecond atomistic simulations directly capture the voltage activation of the Core-MT big potassium channel, revealing novel voltage sensing and sensor-pore coupling mechanisms that have largely eluded the community.

The crystal structure of Sld3CBD-Cdc45 shows its intermolecular interactions, and subsequent Sld3CBD-CMG model construction and binding assays enable a proposal for the mechanism of Cdc45 recruitment and Sld3 release.

The cryptic pocket is critical for one of the VP35 protein's functions and therefore is likely under selective pressure.

Environmental chloride ions act as essential counterions that enable coral opsins to respond to visible light, and the polar residue Glu292 plays a critical role in chloride binding.

The cryoEM structure of a RAD51 displacement loop reveals the molecular mechanism of the strand-exchange reaction at the centre of eukaryotic homologous recombination.

Cryogenic electron microscopy has been used to determine the detailed structure of an intermediate state called a “D-loop” that forms when strands of DNA are exchanged during homologous recombination.