Browse our latest Structural Biology and Molecular Biophysics articles

The C-terminal tail acts as a secondary gate to regulate substrate access into the primary binding site for transport across the membrane.

Cryo-electron microscopy and high-speed atomic force microscopy analyses of an epilepsy-related ligand–receptor complex LGI1–ADAM22 reveal the three-dimensional structure and dynamics of the 3:3 heterohexameric assembly of LGI1–ADAM22.

qFit-ligand is a computational algorithm that enables accurate modeling of multiple conformational states of ligands in X-ray crystallography and cryo-electron microscopy (cryo-EM).

Understanding the dynamics of AdhE enzymes is essential to be able to control the metabolic and energy fluxes in microorganisms used to produce biofuels and biochemicals.

The oligomerization domain of 53BP1, a key DNA repair protein, is a trimer which binds the dimeric hub protein LC8 by a novel mechanism to form dynamic heterogeneous complexes.

Proteomics with PP1-Neurabin fusion proteins identify the 4E-BP proteins as novel Neurabin/PP1 substrates, and interaction with the Neurabin PDZ domain shown to be the major determinant of Neurabin/PP1 substrate specificity.

HiCapR uncovers HIV RNA homodimers and long-range interactions that show structural dynamics critical for viral packaging and assembly.

Cryo-EM structures of HsNCX1 in complex with either phosphatidylinositol 4,5-bisphosphate (a physiological activator) or SEA0400 (a pharmacological inhibitor) provide mechanistic insights into the cellular regulation and pharmacology of NCX proteins.