Browse our latest Structural Biology and Molecular Biophysics articles

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    1. Structural Biology and Molecular Biophysics

    High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter

    Shamayeeta Ray, Samuel P Berry ... Rachelle Gaudet
    Structures of a transition metal transporter spanning the entire Mn2+ transport cycle reveal distinct coordination geometries and dynamic polar networks that enable Mn2+ import, and a Cd2+-bound structure helps explain how Cd2+ behaves differently as a substrate.
    1. Structural Biology and Molecular Biophysics

    Structural and mechanistic insights into the MCM8/9 helicase complex

    Zhuangfeng Weng, Jiefu Zheng ... Yingfang Liu
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes

    Lorena Zuzic, Jan K Marzinek ... Peter J Bond
    Benzene mapping simulations of envelope protein rafts from six different flaviviruses reveal a conserved cryptic site whose cluster of ionisable residues is likely responsible for orchestrating pH-dependent conformational changes during fusion, thereby representing an attractive target for antiviral development.
    1. Structural Biology and Molecular Biophysics

    Transmembrane protein CD69 acts as an S1PR1 agonist

    Hongwen Chen, Yu Qin ... Xiaochun Li
    Cryo-EM in combination with biochemistry, flow cytometry and fluorescence microscopy reveals the activation of S1PR1 by CD69, a type II membrane protein, in cis to induce receptor internalization and thereby disrupt cellular responsiveness to S1P gradients.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Concurrent remodelling of nucleolar 60S subunit precursors by the Rea1 ATPase and Spb4 RNA helicase

    Valentin Mitterer, Matthias Thoms ... Roland Beckmann
    The RNA helicase Spb4 restructures rRNA helices H62/H63 and primes pre-ribosomal 60S intermediates for large-scale remodelling by the AAA-ATPase Rea1.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates

    Hiroshi Yamaguchi, Motohiro Morikawa, Masahide Kikkawa
    Zebrafish genetics and sperm cryo-electron tomography reveal a novel function of Calaxin as a docking complex component stabilizing the outer arm dynein onto the ciliary doublet microtubule.