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    1. Structural Biology and Molecular Biophysics

    On the Polymorph-Selection Determinants of α-Synuclein Amyloid Fibrils Studied at Atomic Resolution

    Lukas Frey, David Rhyner ... Jason Greenwald
    Not revised
    Reviewed Preprint v1
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    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

    Wang Xu, Narendra Kumar Gonepudi ... Maolin Lu
    Antibodies can target multiple conformational states of the HIV envelope to block viral entry, broadening the mechanisms underlying neutralization.
    1. Structural Biology and Molecular Biophysics
    2. Physics of Living Systems

    Thermodynamic principles of enzymatic regulation in biomolecular condensates from reaction-coupled molecular modeling

    Enrico Lavagna, Francesco Delfino ... Alessandro Barducci
    Not revised
    Reviewed Preprint v1
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    From static structures to dynamic landscapes: cryo-EM redefines RNA biology

    Shekhar Jadhav, Spandan Saha ... Marco Marcia
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

    Isaac J Fisher, Kanishka Senarath ... Angeline M Lyon
    Phospholipase Cβ3 is translocated and activated by the heterotrimeric G protein subunit Gαq at the plasma membrane, but the Gβγ heterodimer is required for maximum activation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Distal conformational steering by N-terminal pyroglutamylation enables subtype-selective GPCR activation across Aplysia PRXamide and human Neuromedin U signaling

    Jian-Hui Chang, Wei-Jia Liu ... Jian Jing
    Not revised
    Reviewed Preprint v1
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    1. Structural Biology and Molecular Biophysics

    Bifunctional architecture enables substrate catalysis and channeling in Paracoccus TMAO demethylase

    Trung Thach, KanagaVijayan Dhanabalan ... Ramaswamy Subramanian
    Trimethylamine N-oxide demethylase uses substrate channeling to couple trimethylamine N-oxide demethylation with one-carbon metabolism, safely detoxifying formaldehyde while enhancing metabolic efficiency.
    1. Structural Biology and Molecular Biophysics

    Two Glu/Asp residues cooperatively mediate an early step of ATP hydrolysis in GHKL ATPases MutL and GyrB

    Kenji Fukui, Ayaka Shibuya ... Takato Yano
    A cooperative catalytic mechanism provides a revised framework for understanding ATP hydrolysis in a broad subset of GHKL ATPases.
    1. Structural Biology and Molecular Biophysics

    VDAC2 stabilizes a membrane-inserted, primed intermediate of BAX activation

    Varun Ravishankar, Laidy M Alvero-González ... Lucie Bergdoll
    Not revised
    Reviewed Preprint v1
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    1. Structural Biology and Molecular Biophysics

    In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles

    Zahra Seraj, Ximena Zottig ... Andrei A Korostelev
    Cryogenic electron microscopy of cellular extracts can visualize atomic details and discover new interactions between biological molecules, such as the interactions of the ribosome, the protein-making machinery, with essential proteins to regulate cellular functions.
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