Browse our latest Structural Biology and Molecular Biophysics articles

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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders

    Thibaud Dieudonné et al.
    Single particle cryo-electron microscopy associated with functional studies reveal a critical role of N- and C-terminal tails in the autoinhibition of the disease-related ATP8B1-CDC50A lipid flippase, the possible role of phosphorylation in autoinhibition relief, and strong activation by PI(3,4,5)P3.
    1. Structural Biology and Molecular Biophysics

    Sampling alternative conformational states of transporters and receptors with AlphaFold2

    Diego del Alamo et al.
    Alternative conformations of membrane protein structures can be predicted to high accuracy with AlphaFold2 by reducing the depth of the multiple sequence alignments used for modeling.
    1. Structural Biology and Molecular Biophysics

    Artificial Intelligence: Exploring the conformational diversity of proteins

    Avner Schlessinger, Massimiliano Bonomi
    An artificial intelligence-based method can predict distinct conformational states of membrane transporters and receptors.
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    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Colicin E1 opens its hinge to plug TolC

    S Jimmy Budiardjo et al.
    Bacterial warfare protein colicin E1 opens its hinge to plug antibiotic efflux pump TolC and potentiate antibiotics.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular determinants of complexin clamping and activation function

    Manindra Bera et al.
    Complexin, in conjunction with Synaptotagmin, clamps the SNARE-assembly process under resting conditions and promote vesicle fusion in response to calcium signal.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins

    Paul Lambey et al.
    Experimentally validated structural models of ACKR1-LukE and CCR5-LukE complexes reveal the critical contributions of sulfotyrosine binding sites and divergent loops of Staphylococcus aureus leukotoxins to the recognition of chemokine receptors.
    1. Structural Biology and Molecular Biophysics

    Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates

    Ali A Kermani et al.
    In the bacterial small multidrug transporter EmrE, sidechain rearrangements in the binding site accommodate structurally diverse substrates without major rearrangements of the protein backbone.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Glutathione binding to the plant AtAtm3 transporter and implications for the conformational coupling of ABC transporters

    Chengcheng Fan, Douglas C Rees
    Multiple cryo-electron microscopy structures of a plant ABC transporter exporting glutathione derivatives captured a closed conformation proposed to enforce the export directionality, while a complex central to the coupling mechanism containing both glutathione and closed nucleotide binding domains remains elusive.