Browse our latest Structural Biology and Molecular Biophysics articles

Page 2 of 139
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Geobacter OmcZ filaments suggests extracellular cytochrome polymers evolved independently multiple times

    Fengbin Wang, Chi Ho Chan ... Daniel R Bond
    A cryo-EM structure of the bacterial OmcZ cytochrome filament provides evidence for the possibility that cytochrome polymers had multiple origins in bacteria.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Membrane-mediated dimerization potentiates PIP5K lipid kinase activity

    Scott D Hansen, Albert A Lee ... Jay T Groves
    Dimerization promotes nonlinear kinetics in PIP5K-dependent lipid phosphorylation reactions.
    1. Structural Biology and Molecular Biophysics

    Mars, a molecule archive suite for reproducible analysis and reporting of single-molecule properties from bioimages

    Nadia M Huisjes, Thomas M Retzer ... Karl E Duderstadt
    Mars provides a software platform for the development of complex single-molecule analysis workflows enabling the discovery and reporting of new biological phenomena with an open data format accessible to everyone.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Selenocyanate derived Se-incorporation into the nitrogenase Fe protein cluster

    Trixia M Buscagan, Jens T Kaiser, Douglas C Rees
    X-ray crystal structures capture ATP-dependent chalcogenide exchange from selenocyanate at the nitrogenase Fe protein cluster in the absence of the MoFe protein, an unexpected result as the Fe protein cluster is not traditionally perceived as a site of substrate binding.
    Short Report Updated
    Formats available:
    • HTML
    • PDF
    1. Structural Biology and Molecular Biophysics

    Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor

    Josip Ivica, Hongtao Zhu ... Lucia G Sivilotti
    The sulfonate analog of glycine is very efficacious in activating glycine channels and causes conformational changes in this pentameric ligand-gated channel that are similar to those produced by glycine itself.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Redox-controlled reorganization and flavin strain within the ribonucleotide reductase R2b–NrdI complex monitored by serial femtosecond crystallography

    Juliane John, Oskar Aurelius ... Martin Högbom
    The flavoprotein NrdI in class Ib ribonucleotide reductase controls superoxide generation and metal site oxidation by tuning the redox properties of its flavin cofactor via steric strain induced by the formation of the R2b–NrdI protein complex.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule analysis of the entire perfringolysin O pore formation pathway

    Conall Mc Guinness, James C Walsh ... Till Böcking
    Arc-shaped PFO oligomers consisting of at least four subunits can insert into the membrane in a kinetically controlled process opening a transmembrane pore, whereby post-insertion growth may ultimately lead to formation of a complete ring.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 –tubulin complex

    Shinya Taguchi, Juri Nakano ... Ryo Nitta
    Structural, functional, and genetic analyses reveal how kinesin-4 motor KLP-12 precisely modulates the curvature of the microtubule plus-end to inhibit the microtubule dynamics for achieving the proper length control of axons.