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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

    Samantha J Cassell, Weiyan Li ... Jonathan R Whicher
    Not revised
    Reviewed Preprint v1
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    • Convincing
    1. Structural Biology and Molecular Biophysics

    The molecular infrastructure of glutamatergic synapses in the mammalian forebrain

    Julia Peukes, Charlie Lovatt ... René A Frank
    Revised
    Reviewed Preprint v2
    Updated
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    1. Structural Biology and Molecular Biophysics

    A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis

    Ivana Petrovic, Samit Desai ... Stephan Grzesiek
    Not revised
    Reviewed Preprint v1
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    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Atomistic Simulation of Voltage Activation of a Truncated BK Channel

    Zhiguang Jia, Jianhan Chen
    Revised
    Reviewed Preprint v3
    Updated
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    • Solid
    1. Structural Biology and Molecular Biophysics

    Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division

    Jianwei Li, Yutong He ... Min Luo
    Revised
    Reviewed Preprint v2
    Updated
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    • Solid
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Prebiotic gas flow environment enables isothermal nucleic acid replication

    Philipp Schwintek, Emre Eren ... Dieter Braun
    Exponential nucleic acid replication can occur isothermally in a prebiotically plausible setting that accumulates and simultaneously separates the strands of nucleic acids through evaporation-driven flows at the gas–water interface.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes

    Janelle JY Chuah, Madalena R Daugherty, David M Smith
    Revised
    Reviewed Preprint v2
    Updated
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    • Convincing
    1. Structural Biology and Molecular Biophysics

    The C-terminus of the multi-drug efflux pump EmrE prevents proton leak by gating transport

    Merissa Brousseau, Da Teng ... Katherine A Henzler-Wildman
    The C-terminal tail acts as a secondary gate to regulate substrate access into the primary binding site for transport across the membrane.
    1. Structural Biology and Molecular Biophysics

    Insights from aquaporin structures into drug-resistant sleeping sickness

    Modestas Matusevicius, Robin A Corey ... Simone N Weyand
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Structural insights into heterohexameric assembly of epilepsy-related ligand–receptor complex LGI1–ADAM22

    Takayuki Yamaguchi, Kei Okatsu ... Shuya Fukai
    Cryo-electron microscopy and high-speed atomic force microscopy analyses of an epilepsy-related ligand–receptor complex LGI1–ADAM22 reveal the three-dimensional structure and dynamics of the 3:3 heterohexameric assembly of LGI1–ADAM22.
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