Browse our latest Structural Biology and Molecular Biophysics articles

Page 2 of 145
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub

    Martin Wilkinson, Oliver J Wilkinson ... Mark S Dillingham
    New cryoEM structures reveal how small bacteriophage proteins suppress bacterial immunity.
    1. Structural Biology and Molecular Biophysics

    Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain

    Phuong T Nguyen, Hai M Nguyen ... Vladimir Yarov-Yarovoy
    Rationally designed peptide inhibitors of human voltage-gated channels have transformative potential to define a new class of biologics to treat pain.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Evolutionary divergence in the conformational landscapes of tyrosine vs serine/threonine kinases

    Joan Gizzio, Abhishek Thakur ... Ronald M Levy
    Computational methods based on both sequence and structure show evidence that tyrosine kinases are energetically biased to populate the 'DFG-out' type-II inhibitor binding conformation relative to serine/threonine kinases.
    1. Structural Biology and Molecular Biophysics

    A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0

    Jasenko Zivanov, Joaquín Otón ... Sjors HW Scheres
    New functionality in RELION-4.0 allows convenient structure determination from cryo electron tomography data to resolutions sufficient for de novo atomic modelling.
    1. Genetics and Genomics
    2. Structural Biology and Molecular Biophysics

    Structure-guided isoform identification for the human transcriptome

    Markus J Sommer, Sooyoung Cha ... Steven L Salzberg
    The ability to accurately predict a protein's structure gives us an entirely new way to annotate the human genome.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Calcium dependence of both lobes of calmodulin is involved in binding to a cytoplasmic domain of SK channels

    David B Halling, Ashley E Philpo, Richard W Aldrich
    Calcium drives interactions for both calcium-binding domains of calmodulin in complex with KCa2.1 peptides and both domains are required for normal channel function.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Working strokes produced by curling protofilaments at disassembling microtubule tips can be biochemically tuned and vary with species

    Lucas E Murray, Haein Kim ... Charles L Asbury
    Laser trap measurements show that mechanical work output from curling protofilaments is enhanced by adding magnesium, and that yeast microtubules generate larger and more energetic working strokes than bovine microtubules.