Browse our latest Structural Biology and Molecular Biophysics articles

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    1. Structural Biology and Molecular Biophysics

    Structural mechanisms for VMAT2 inhibition by tetrabenazine

    Michael P. Dalton, Mary Hongying Cheng ... Jonathan A. Coleman
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure

    KM Rifat Faysal, James C Walsh ... Till Böcking
    The anti-HIV drug lenacapavir breaks the HIV capsid by stabilising regions of low curvature at the expense of maintaining a closed shell, leading to loss of viral DNA synthesis and inhibition of infection.
    1. Structural Biology and Molecular Biophysics

    Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

    Michael J Currie, James S Davies ... Rachel A North
    Structure of the dimeric Haemophilus influenzae TRAP transporter (SiaQM) reveals two Na+ sites, the substrate-binding site and lipid-binding sites, and weak but promiscuous binding of SiaP to SiaQM.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism

    Mengyuan Xu, Torben Neelands ... Merritt Maduke
    A combination of high-resolution structure determination, electrophysiology, and MD simulations reveal fundamental insight into the molecular function of voltage-gated chloride channels.
    1. Structural Biology and Molecular Biophysics

    Novel sterol binding domains in bacteria

    Liting Zhai, Amber C Bonds ... Laura MK Dassama
    A combination of bioinformatics, protein biochemistry, and X-ray crystal structures reveals new bacterial proteins that are capable of binding to sterols.