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    1. Structural Biology and Molecular Biophysics

    Lenacapavir-induced lattice hyperstabilization is central to HIV-1 capsid failure at the nuclear pore complex and in the cytoplasm

    Arpa Hudait, Ryan C Burdick ... Gregory A Voth
    Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Rescuing the Function of Missense-Mutated Tumor Suppressor VHL using Stabilizing Small Molecules

    Mariam Ahmed Fouad, Christopher S Parry ... John Karanicolas
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    A membrane insertion code for intrinsically disordered proteins

    Fidha Nazreen Kunnath Muhammedkutty, Huan-Xiang Zhou
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    In-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association

    Tamar Basiashvili, Joshua Hutchings ... Elizabeth Villa
    Revised
    Reviewed Preprint v2
    Updated
    • Important
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    1. Structural Biology and Molecular Biophysics

    Conformational variability of HIV-1 Env trimer and viral vulnerability

    Yiwei Cao, Wonpil Im
    Large-scale all-atom simulations of a full-length, glycosylated HIV-1 Env trimer in an asymmetric membrane reveal a rigid ectodomain and highly diverse conformational landscapes in the membrane-proximal region and transmembrane domain.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the recruitment of viral type 2 IRES to ribosomal preinitiation complex for protein synthesis

    Deepakash Das, Tanweer Hussain
    The viral type 2 internal ribosome entry site uses a unique mechanism to hijack the host ribosomal machinery by interacting with initiator tRNA and 40S head.
    1. Structural Biology and Molecular Biophysics

    Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling

    Nevin K Zacharia, Stefanie Kuhns ... Esben Lorentzen
    The IFT172 C-terminus bridges IFT-A and IFT-B complexes through mutually exclusive interactions with IFT140 and IFT144, and harbors a U-box-like domain linking intraflagellar transport to ubiquitin-dependent ciliary signaling.
    1. Structural Biology and Molecular Biophysics

    Optimising the tilt-increment for in situ cryo-electron tomography

    Maarten W Tuijtel, Tomáš Majtner ... Martin Beck
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

    Kexin Zhang, Timothy Grant, Nikolaus Grigorieff
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Myristoylation licenses disordered viral VP4 protein to anchor to and perforate the membrane through phase separation

    Sichao Huang, Fengzhen Deng ... Bin Sun
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
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