Browse our latest Structural Biology and Molecular Biophysics articles

Reducing vertical forces reveals kinesin-1 as a robust motor capable of sustaining high loads and efficiently generating large collective forces with multiple motors.

RNA differentially regulates the assembly pathways of bacterial and host α-helical peptides, revealing supramolecular architecture as a tunable determinant of cytotoxic and antimicrobial function.

Computer-Aided Aptamer Modeling and Optimization (CAAMO) enables structure-guided RNA aptamer affinity maturation, producing a SARS-CoV-2 RBD (receptor binding domain) binder that rivals neutralizing antibodies and retains predicted activity across variants.

Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.

Large-scale all-atom simulations of a full-length, glycosylated HIV-1 Env trimer in an asymmetric membrane reveal a rigid ectodomain and highly diverse conformational landscapes in the membrane-proximal region and transmembrane domain.

The viral type 2 internal ribosome entry site uses a unique mechanism to hijack the host ribosomal machinery by interacting with initiator tRNA and 40S head.