Browse our latest Structural Biology and Molecular Biophysics articles

Structures of a transition metal transporter spanning the entire Mn²⁺ transport cycle reveal distinct coordination geometries and dynamic polar networks that enable Mn²⁺ import, and a Cd²⁺-bound structure helps explain how Cd²⁺ behaves differently as a substrate.

Benzene mapping simulations of envelope protein rafts from six different flaviviruses reveal a conserved cryptic site whose cluster of ionisable residues is likely responsible for orchestrating pH-dependent conformational changes during fusion, thereby representing an attractive target for antiviral development.

Cryo-EM in combination with biochemistry, flow cytometry and fluorescence microscopy reveals the activation of S1PR1 by CD69, a type II membrane protein, in cis to induce receptor internalization and thereby disrupt cellular responsiveness to S1P gradients.

The RNA helicase Spb4 restructures rRNA helices H62/H63 and primes pre-ribosomal 60S intermediates for large-scale remodelling by the AAA-ATPase Rea1.

Zebrafish genetics and sperm cryo-electron tomography reveal a novel function of Calaxin as a docking complex component stabilizing the outer arm dynein onto the ciliary doublet microtubule.