Browse our latest Structural Biology and Molecular Biophysics articles

A cooperative catalytic mechanism provides a revised framework for understanding ATP hydrolysis in a broad subset of GHKL ATPases.

Cryogenic electron microscopy of cellular extracts can visualize atomic details and discover new interactions between biological molecules, such as the interactions of the ribosome, the protein-making machinery, with essential proteins to regulate cellular functions.

Evolutionarily unrelated microtubule and actin regulatory factors use the same mechanism to accelerate polymerization.

A lamprey KCNE protein provides insight into the early evolution of vertebrate potassium-channel regulation.

A sequence-based method dubbed AroMIP predicts the membrane insertion propensities of aromatic-centered motifs, thereby advancing mechanistic understanding of membrane insertion and enriching the tools for studying intrinsically disordered protein (IDP)-membrane association.

For in situ cryo-electron tomography, smaller tilt increments yield better-aligned tilt-series and higher-quality tomograms, with a 3° increment resulting in optimal subtomogram averaging resolution.

Label-free optical imaging provides a direct readout of relaxed myosin conformational states in skeletal and cardiac muscle.

Cryo-electron microscopy structure of human G-protein-coupled receptor 30 in the presence of bicarbonate ions revealed unique extracellular pockets and critical residues for bicarbonate binding and activation.