Browse our latest Structural Biology and Molecular Biophysics articles

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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1

    Karolina Honzejkova, Dalibor Kosek ... Tomas Obsil
    Thioredoxin functions as a negative allosteric effector of ASK1 by altering the interaction between the thioredoxin-binding and tetratricopeptide repeats domains, thereby reducing access to the kinase domain's activation segment.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock

    Daniyal Tariq, Nicole Maurici ... Brian R Crane
    The intrinsic disorder of the circadian clock protein Frequency organizes binding partners, facilitates liquid–liquid phase separation, modulates Frequency phosphorylation, and derives from sequence properties conserved with homologous clock components.
    1. Structural Biology and Molecular Biophysics

    Conformational dynamics of a nicotinic receptor neurotransmitter binding site

    Mrityunjay Singh, Dinesh C. Indurthi ... Shailendra Asthana