Browse our latest Structural Biology and Molecular Biophysics articles

Page 3 of 147
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication

    Robert LeDesma, Brigitte Heller ... Alexander Ploss
    A combined computational, genetic, and biochemical analysis of the hepatitis E virus open reading frame 1 (ORF1) protein identifies a novel domain-domain interaction that is vital for fitness and supports a proposed structural model of the ORF1 polyprotein.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase

    Zhuoran Zhao, Xiayu Shen ... Shozeb Haider
    Extremely significant interactions between α3-β7 and β12-α5 loops in the tetrameric L1 metallo-β-lactamase play an important role in the structural remodeling of the active site and offer insights into the potential for novel drug development by exploiting these interactions.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Dunaliella photosystem II reveals conformational flexibility of stacked and unstacked supercomplexes

    Ido Caspy, Maria Fadeeva ... Nathan Nelson
    Photosystem II, the pigment-protein complex responsible for water oxidation in photosynthesis, was found to exist in two different core conformations with altered antennae connectivity.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution

    Josep Martí-Solans, Aina Børve ... Timothy Lynagh
    Expression patterns and biophysical properties of acid-sensing ion channels in numerous bilaterian animals offer insight into the deployment of ion channels by the evolving nervous system in complex animals.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into actin isoforms

    Amandeep Singh Arora, Hsiang-Ling Huang ... Krishna Chinthalapudi
    1. Structural Biology and Molecular Biophysics

    State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MscS ion channels

    Yein Christina Park, Bharat Reddy ... José D Faraldo-Gómez
    A theory is presented that explains why some ion channels tend to open in response to membrane stretching, which posits that channel closing is disfavored by the morphological energetics of the lipid bilayer, and increasingly so under lateral tension.
    1. Structural Biology and Molecular Biophysics

    Activation-pathway transitions in human voltage-gated proton channels revealed by a non-canonical fluorescent amino acid

    Esteban Suárez-Delgado, Maru Orozco-Contreras ... Leon D Islas
    Combined patch-clamp fluorometry with ANAP, a fluorescent non-canonical amino acid, uncovers transitions in the activation pathway of human HV1 that are modulated by voltage and the pH gradient.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Targeting RNA:protein interactions with an integrative approach leads to the identification of potent YBX1 inhibitors

    Krystel El Hage, Nicolas Babault ... David Pastré
    The development of an integrative computational-experimental approach for identifying small molecules that can disrupt RNA:protein interactions in vitro and in cells led to the identification of several inhibitors of YBX1 in the micromolar range, including a previously approved drug.
    1. Structural Biology and Molecular Biophysics

    The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

    Alexandria N Miller, Patrick R Houlihan ... David E Clapham
    SARS coronaviruses encode several mysterious proteins such as Orf3a and, in contrast to what has been claimed, Orf3a is not an ion channel but rather disrupts cellular trafficking by binding to the protein sorting complex known as HOPS.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    RNA sequence to structure analysis from comprehensive pairwise mutagenesis of multiple self-cleaving ribozymes

    Jessica M Roberts, James D Beck ... Eric J Hayden
    A high-throughput analysis of several self-cleaving ribozymes reveals the effect of every possible mutation, and every possible pair of mutations, and how patterns in the relative activity data can be mapped to canonical and non-canonical structural elements.