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    1. Structural Biology and Molecular Biophysics

    Ais: streamlining segmentation of cryo-electron tomography datasets

    Mart GF Last, Leoni Abendstein ... Thomas H Sharp
    Revised
    Reviewed Preprint v2
    Updated
    1. Structural Biology and Molecular Biophysics

    Ligand-Coupled Conformational Changes in a Cyclic Nucleotide-Gated Ion Channel Revealed by Time-Resolved Transition Metal Ion FRET

    Pierce Eggan, Sharona E Gordon, William N Zagotta
    Revised
    Reviewed Preprint v2
    Updated
    1. Structural Biology and Molecular Biophysics

    Structural and functional insights into Cdc45 recruitment by Sld7– Sld3 for CMG complex formation

    Hao Li, Izumi Ishizaki ... Min Yao
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    CTFFIND5 provides improved insight into quality, tilt and thickness of TEM samples

    Johannes Elferich, Lingli Kong ... Nikolaus Grigorieff
    Revised
    Reviewed Preprint v2
    Updated
    1. Structural Biology and Molecular Biophysics

    Functional implications of the exon 9 splice insert in GluK1 kainate receptors

    Surbhi Dhingra, Prachi M Chopade ... Janesh Kumar
    GluK1-1 splice variant alters the gating properties of kainate receptors, providing crucial insights into receptor modulation by auxiliary proteins and advancing the understanding of synaptic transmission.
    1. Structural Biology and Molecular Biophysics

    TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids

    Augustus J Lowry, Pengfei Liang ... Yang Zhang
    Proteins in the Transmembrane Channel-Scramblase (TCS) superfamily share an evolutionarily conserved ability to permeate ions and phospholipids, challenging distinctions between ion channels and lipid scramblases.
    1. Structural Biology and Molecular Biophysics

    Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

    Aya Matsui, Cathy Spangler ... Eric Gouaux
    By harnessing antibody fragments conjugated to small gold nanoparticles together with high pressure freezing, FIB/SEM milling and cryo-electron tomography, AMPA receptors were identified from mouse brain tissue.
    1. Structural Biology and Molecular Biophysics

    Conservation of the cooling agent binding pocket within the TRPM subfamily

    Kate Huffer, Matthew CS Denley ... Kenton J Swartz
    The cooling agent pocket in TRPM8 is conserved in a subset of other TRPM channels and the cooling agent icilin can regulate opening of TRPM4 channels in response to calcium and voltage.
    1. Structural Biology and Molecular Biophysics

    PUFA stabilizes a conductive state of the selectivity filter in IKs channels

    Alessia Golluscio, Jodene Eldstrom ... H Peter Larsson
    Polyunsaturated fatty acids activate IKs channels by stabilizing a conductive state of the selectivity filter.
    1. Structural Biology and Molecular Biophysics

    Predicting the sequence-dependent backbone dynamics of intrinsically disordered proteins

    Sanbo Qin, Huan-Xiang Zhou
    SeqDYN, a sequence-based method, accurately predicts the residue-specific transverse relaxation rates of intrinsically disordered proteins.
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