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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Harnessing AlphaFold to reveal hERG channel conformational state secrets

    Khoa Ngo, Pei-Chi Yang ... Igor Vorobyov
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    The Structural Dynamics of IRE1 and its Interaction with Unfolded Peptides

    Elena Spinetti, G Elif Karagöz, Roberto Covino
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes

    Janelle JY Chuah, Madalena R Daugherty, David M Smith
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus

    Wenfei Song, Jan Fiala ... Friedrich Förster
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

    Jing Xue, Weizhong Zeng ... Youxing Jiang
    Cryo-EM structures of HsNCX1 in complex with either phosphatidylinositol 4,5-bisphosphate (a physiological activator) or SEA0400 (a pharmacological inhibitor) provide mechanistic insights into the cellular regulation and pharmacology of NCX proteins.
    1. Structural Biology and Molecular Biophysics

    p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners

    Anamari Brdar, Christian Osterburg ... Volker Dötsch
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Structural mechanism of strand exchange by the RAD51 filament

    Luay Joudeh, Robert E Appleby ... Luca Pellegrini
    Not revised
    Reviewed Preprint v1
    • Landmark
    • Compelling
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Reliable protein–protein docking with AlphaFold, Rosetta, and replica exchange

    Ameya Harmalkar, Sergey Lyskov, Jeffrey J Gray
    New protein-protein docking algorithm combining deep learning (AlphaFold2) and physics (Rosetta and enhanced sampling) achieves high success rates.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers

    Robert G Stewart, Matthew James Marquis ... Jon T Sack
    Drugs are identified that unmask molecular origins of certain neuronal potassium currents, enabling functional analysis of previously indistinguishable potassium channel subtypes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers

    Xiaoyu Yu, Yuanjun He ... Douglas J Kojetin
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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