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ADP-ribosylation factor-like GTPase 15, an atypical small GTPase, binds to cystathionine-β-synthase-pair domain divalent metal cation transport mediator (CNNM) membrane proteins to inhibit divalent cation efflux by CNNM proteins and influx by transient receptor potential ion channel subfamily M member 7.

Cryo-EM structures of Cys-loop receptor Alpo4 from the thermophilic worm Alvinella pompejana show that a sterol derivative CHAPS binds in and outside of its orthosteric binding site and induces a quaternary twist.

The lysine/glutamic acid/arginine region in chromatin assembly factor (CAF-1) forms a long single alpha-helix DNA-binding domain, facilitating the recognition of tetrasome-length DNA and linking functional domains within the CAF-1 architecture for efficient tetrasome assembly after DNA synthesis.

Changing substituents on the aromatic rings of polyunsaturated fatty acid analogues tailors their activation effect on the I_Ks channel and thus their therapeutic potential for long QT syndrome.

Regulation of phosphoinositide 3 kinase (PI3Kγ) is essential in immune function, and stimuli that modulate the dynamics of the PI3Kγ helical domain can activate or inhibit kinase activity.

Using state-specific contacts inferred from coevolving residue pairs enables us to build models of the various conformational states along the sugar porter functional cycle and reconstruct the free-energy landscape of the process.

Live-cell single-molecule imaging of DNA repair factors can be used to analyze their localization to DNA lesions and dissect the hierarchy of their recruitment.

The HCN1 channel gates thanks to a coupling mechanism involving the reorganization of the interfaces between the voltage-sensor domains and pore helices, subtly shifting the balance between hydrophobic and hydrophilic interactions in a 'domino effect'.

Efficiency measures the fundamental link between agonist binding and protein conformational change, and in nicotinic receptors has 5 values that calibrate energy changes in the induced fit that triggers activation.