Browse our latest Structural Biology and Molecular Biophysics articles

The 3D structure of the six-subunit complex and its polymeric assembly gives insights into cargo transport in cilia and how specific mutations in these genes lead to ciliopathy birth defects.

Guided by the available cryo-EM structure of the KCNQ1-KCNE3 ion channel complex, the critical role of the S1 segment of the voltage-sensor domain in the gating modulation by KCNE3 is revealed.

Cryo-electron microscopy reveals previously undescribed structural features of choanoflagellate flagella and provides new insights into flagellar evolution.

Deep mutational scanning of homologous proteins shows conservation in allosteric mechanisms but differences in molecular details within the protein family.

The serine phosphorylated and inhibited KdpFABC complex (KdpFAB_S162-PC) adopts an off-cycle E1P tight state, due to an impaired E1P/E2P transition.

The core of histone acetyltransferase complex, NuA4, flexibly tethers various histone recognition modules, including the HAT module which is capable of binding nucleosomes marked by H3K4me3 and H3 acetylation.

A cryo-EM structure of the SARS-CoV-2 M protein, the most abundant protein in the viral envelope, provides insight into its essential role in virus assembly.

Molecular dynamics simulation of the full-length TSH receptor, a major human autoantigen whose full structure remains uncertain, showed that its linker region is an intrinsically disordered protein, explaining the difficulty of obtaining an experimental structure.

The combination of cellular cryo-electron tomography, biochemistry, and mathematical modeling provides the first integrated structural model of the Alphavirus replication organelle.

Three-dimensional structure of CRISPR Cas7-11 shed light on protein evolution and guide development of biotechnology for RNA manipulations in cells.