Browse our latest Structural Biology and Molecular Biophysics articles

KASH5 uses an EF-hand domain to directly interact with the light intermediate chain of dynein, promotes processive dynein motility, and facilitates dynein recruitment to the nuclear envelope during prophase I of meiosis.

Inhibiyiton of the lysosomal chloride-proton antiporter ClC-7 by the signaling lipid PI(3,5)P2 is important for lysosomal pH maintenance and is disrupted by a disease-causing gain-of-function mutation.

Novel insights into the molecular mechanisms underlying neurotransmitter release are provided by all-atom molecular dynamics simulations including SNARE proteins, synaptotagmin-1, complexin-1, a vesicle and a flat bilayer.

CAMSAP2 co-condensates with αβ-tubulin to induce microtubule nucleation and growth, serving as a microtubule-organizing centre for non-centrosomal microtubules.

Cryo-EM structures of two types of prokaryotic Phosphoribosyl pyrophosphate synthase filaments reveal that filamentation into cytoophidia provides a new layer of metabolic regulation.

Stress sensors in the membrane of the endoplasmic reticulum respond to the accumulation of unfolded proteins by briefly forming small phosphorylation-competent oligomers and dissolving back into active dimers.

Streptococcus pyogenes M87 protein unfurls its coiled coil to capture and neutralize the human antimicrobial peptide LL-37.

PLC-γ isozymes are activated by a combination of receptor engagement and membrane proximity.

Because voltage-gated KCNQ2 channels are central to physiological and pathophysiological events, understanding how disease-causing mutations in different channel regions disrupt function will help future development of mutation-specific antiepileptic therapies.

Phenotypic heterogeneity at the single-cell level of cellulosomal machinery biosynthesis suggests a division-of-labor strategy as revealed by the nanoscale mechanistic and ecological investigation of in situ structure and distribution of cellulosomes on bacteria while interacting with the cellulosic substrate.