Browse our latest Structural Biology and Molecular Biophysics articles

A physics-based, statistically rigorous mathematical model enables automated, objective interpretation of images from single-molecule fluorescence colocalization microscopy experiments.

An amino acid dimorphism in HLA-C with an established impact on natural killer cell receptors plays an unexpected and significant role in T cell receptor recognition of HLA-C with relevance for tumor immunity.

Polyunsaturated fatty acids facilitate or impede Kv7 channel activation, depending on channel subtype and their dominant functional site(s).

The cryogenic-electron microscopy structure of IL-27 bound to receptors, IL-27Rα and gp130, revealing a three-site assembly mechanism and overall topology and molecular details reminiscent of IL-6 but distinct from related IL-12 and IL-23.

Cryogenic super-resolution microscopy resolves the three-dimensional arrangement of individual fluorescent markers attached to protein complexes with Angstrom precision through their blinking behavior, polarization selection and a classification scheme.

Genetically induced conformational modulation of eIF2B activates the Integrated Stress Response by impairing nucleotide exchange.

The energetic costs of ion dehydration in the pore of human TMEM175 determine its ion selectivity.

Analytical techniques and computational models reveal novel post-translational modifications on β-myosin heavy chain in the human hearts and highlight their potential as therapeutic targets.

Doublecortin activates its C-terminal domain when its N-terminal domain engages the microtubule lattice, leading to self-associations that explain the stabilizing effect of Doublecortin in neuronal migration.

The functions of seipin in triacylglycerol nucleation and lipid droplet maturation are studied with all-atom and coarse-grained simulations along with cell experiments, providing a novel model for lipid droplet formation.