Browse our latest Structural Biology and Molecular Biophysics articles

Cryo-EM analysis of full-length human epidermal growth factor receptor provides a molecular explanation for how ligand-induced differential effect in the ligand-binding extracellular module tunes the transmembrane signaling mediated by epidermal growth factor receptor.

Asp234 is deprotonated in the ground state and forms the proton transfer pathway that proceeds from the Schiff base toward Glu68 in the intermediate state of the anion channelrhodopsin GtACR1.

Uniform diameter and curvature of the outer membrane extensions and vesicles of Shewanella oneidensis are maintained by a bacterial Bin/Amphiphysin/Rvs (BAR) domain-like protein BdpA.

The striking reduction in open probability of CFTR channels harboring the R117H cystic fibrosis mutation is caused by loss of a strong hydrogen bond between positions 117 and 1124, which is formed in wild-type channels selectively in the open state.

Biochemical and structural investigations of the human tRNA ligase complex reveal the details of its molecular assembly and provide insights into the reaction mechanism of its catalytic subunit.

Unidirectional crosstalk occurs between signaling competent EGFR dimers activating RON within heteromeric complexes at the plasma membrane.

Single-molecule FRET measurements and protein crosslinking reveal the compact structure of quiescent STIM1 and the conformational rearrangements that enable it to activate store-operated calcium entry.

Harnessing single-molecule FRET illuminates the structural changes necessary for a protein to fine-tune the influx of calcium when reserves inside a cell run low.

Electron paramagnetic resonance spectroscopy quantitatively correlates structural damages of serum albumin with COVID-19 severity and mortality thus suggesting albumin replacement therapy as a strategy to rescue patients at risk of mortality.

The yeast enzyme CTP synthase assembles inactive filaments that are driven to polymerization through the drop in cytoplasmic pH accompanying starvation.