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    1. Neuroscience

    A differentiable model for optimizing the genetic drivers of synaptogenesis

    Tommaso Boccato, Matteo Ferrante, Nicola Toschi
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Ecology

    The urban tree of life: quantifying relationships between body size and urban tolerance for more than 30,000 plant and animal species

    Corey T Callaghan, Diana E Bowler ... Thomas Merckx
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling

    Stephan Tetenborg, Eyad Shihabeddin ... John O’Brien
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Continuous developmental changes in word recognition support language learning across early childhood

    Michael C Frank, Virginia A Marchman ... Martin Zettersten
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Spatial learning in multi-scale environments: Roles of hippocampus, orbitofrontal cortex, and retrosplenial cortex

    Yidan Qiu, Senning Zheng ... Ruiwang Huang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Computational and Systems Biology

    Generative modeling for RNA splicing prediction and design

    Di Wu, Natalie Maus ... Yoseph Barash
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    Locus coeruleus modulation of single-cell representation and population dynamics in the mouse prefrontal cortex during attentional switching

    Marco Nigro, Lucas Silva Tortorelli ... Hongdian Yang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Cancer Biology

    Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

    Jessica Armand, Sungsoo Kim ... Hee Won Yang
    Maintaining CDK4/6 inhibition constrains drug‑resistant breast tumors by delaying cell‑cycle entry, and adding CDK2 inhibition further deepens control to guide post‑progression therapy.
    1. Microbiology and Infectious Disease

    A system for functional studies of the major virulence factor of malaria parasites

    Jakob Cronshagen, Johannes Allweier ... Tobias Spielmann
    The generation of malaria parasites expressing only one of the multiple variants of their most important virulence factor enables the study of different aspects of this virulence factor.
    1. Medicine
    2. Neuroscience

    Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia

    Naidi Sun, Yu-Yo Sun ... Song Hu
    Post‑HI oxidative‑phosphorylation uncoupling drives secondary energy failure in neonatal brains, and preventing the post‑HI CMRO2 surge is a key mechanism underlying hypothermia’s neuroprotection.
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