Chrispin Chaguza, Daan W Arends ... Amelieke JH Cremers
The pneumococcal capsular serotype and genetic background, as well as a combination of genomic loci, influence intrinsic pneumococcal growth kinetics, which may have implications for pneumococcal disease pathogenesis.
Pharmacological disruption of TopBP1 condensation impairs ATR signaling, promotes DNA damage and apoptosis, and enhances the efficacy of FOLFIRI chemotherapy in colorectal cancer.
Rotation of the transient receptor potential (TRP) domain appears to be a universal mechanism for gating of the TRP channel family, including the mechanosensitive ion channel NOMPC.
Noelle L Koonce, Sarah E Emerson ... Daniel A Colón-Ramos
NeuroSC provides an open-source framework for comparative connectomics, integrating neuronal morphologies, contacts, and synapses across developmental stages and datasets.
There is significant information about continuous 3D tongue direction contained in the primate orofacial sensorimotor cortex during untrained tasks, and alterations to tongue kinematics and directional tuning with temporarily induced sensory loss.
A modified rabies-based circuit-mapping strategy combined with physiology, optogenetics, and behavior identifies asymmetric corticostriatal subcircuits that exert distinct control over actions.
Nare Karagulyan, Maja Überegger ... Christine Bandtlow
Loss of RTN4RL2 disrupts synapse formation and function between inner hair cells and spiral ganglion neurons, leading to elevated auditory thresholds and highlighting its critical role in hearing.
A novel connectomics approach reveals synaptic connectivity differences between narrowly and broadly tuned olfactory glomeruli in Drosophila melanogaster, providing new insights into glomerular circuitry and its putative computational roles.
