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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the folding of PINK1 by the HSP90–CDC37 chaperone complex

    Kei Okatsu, Hayato Yamamoto ... Shuya Fukai
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Microbiology and Infectious Disease

    Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei

    Sourav Banerjee, Nicola Minshall ... Mark Carrington
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Neuroscience

    Flexible neural representations of abstract structural knowledge in the human entorhinal cortex

    Shirley Mark, Philipp Schwartenbeck ... Timothy E Behrens
    A novel fMRI method reveals that humans generalize task structure across non-aligned state spaces, showing entorhinal representations support flexible knowledge transfer.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Massively parallel reporter assay for mapping gene-specific regulatory regions at single-nucleotide resolution

    Alastair J Tulloch, Ryan Nicholas Delgado ... Constance L Cepko
    Integrated locus-specific and mutational MPRAs reveal regulatory modules and nucleotide determinants governing cell type-specific gene expression, providing a scalable framework for mapping cis-regulatory architecture.
    1. Plant Biology

    The influence of heavy metal stress on the evolutionary transition of teosinte to maize

    Jonathan Acosta-Bayona, Miguel Vallebueno-Estrada, Jean-Philippe Vielle-Calzada
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

    Jennifer Kosmatka, Cong Liu ... Amy E Keating
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    RNA Selectively Modulates Activity of Virulent Amyloid PSMα3 and Host Defense LL-37 via Phase Separation and Aggregation Dynamics

    Bader Rayan, Eilon Barnea ... Meytal Landau
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology
    2. Neuroscience

    Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons

    Daniel Beaudet, Christopher L Berger, Adam G Hendricks
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Solid
    1. Neuroscience

    Size tuning of neural response variability in laminar circuits of macaque primary visual cortex

    Lauri Nurminen, Maryam Bijanzadeh, Alessandra Angelucci
    The trial-to-trial variability of neuronal responses and the correlated response variability among neurons are modulated by visual stimulus size in a manner that depends on cortical layer, suggesting multiple circuits and mechanisms as the source of variability.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synthetic gene circuits that selectively target RAS-driven cancers

    Gabriel Valentin Senn, Leon Nissen, Yaakov Benenson
    Design and integration of various biomolecular sensors for over-activated rat sarcoma (RAS) created synthetic gene circuits that distinguish mutant versus wild-type signaling and express a therapeutic protein to kill RAS-driven cancer cells.
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