Abdulkadir Ozkan, Hari K Padmanabhan ... Jeffrey D Macklis
Developmentally-based directed differentiation from cortical progenitors sets a foundation for in vitro mechanistic and therapeutic disease modeling, and toward regenerative neuronal repopulation and circuit repair.
A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive interferon responses.
Durafshan Sakeena Syed, Primoz Ravbar, Julie H Simpson
Anatomical and behavioral characterization of inhibitory neurons in the Drosophila ventral nerve cord shows their critical, diverse roles in limb coordination.
Bidirectional modulation of the activity of the synaptic protein mGluR5 alters spontaneous mouse motor behavior and produces correlated changes in co-activity patterns among direct pathway neurons in the dorsal striatum.
Developmental electrophysiological adaptations and heat-sensitive proteins, such as TRPV3, in cortical excitatory neurons help maintain stable activity levels when brain temperature rises by 2–3°C during fever.
Amanda L Hughes, Ramasubramanian Sundaramoorthy, Tom Owen-Hughes
Structures of the chromatin remodelling enzyme Chd1 during ongoing reactions reveal a reaction pathway tuned to generate nucleosome spacing similar to that observed in cells.
