NALCN and TRPC6 drive the subthreshold depolarization of VTA DA neurons and down regulation of TRPC6 contributes to reduced VTA DA neuron firing and chronic stress-induced depression-like behavior of mice.
Cryo-electron tomography uncovers the flexible, filamentous architecture of mouse ciliary rootlets and their regular cross-striations with extensive membrane connections.
A single-nucleus atlas of bone repair uncovers the trajectories of periosteal skeletal stem/progenitor cells in response to fracture and identifies injury-induced fibrogenic cells as intermediate osteochondroprogenitors and key paracrine regulators.
Maternal obesity mouse model reveal that melatonin deficiency causes the genomic hyper-methylation of oocytes via increasing the expression of DNA methyltransferases.
Bikash Adhikari, Katharina Schneider ... Elmar Wolf
A rapamycin-induced proximity assay enables rapid identification of optimal E3 ligases for target protein degradation in living cells, streamlining early-stage proteolysis targeting chimera development.
Poor intracellular availability and diffusion of weakly basic, small molecule drugs can be greatly enhanced by preventing ion trapping in crowded cellular environments.
In metastatic NSCLC patients, CHIP showed minimal impact on immunotherapy response but was more prevalent and associated with inflammatory pathways in myeloid cells, particularly in lung squamous cell carcinoma.
The mirror-symmetric structure of the Caenorhabditis elegans gonad is established through the Wnt-independent function of a Frizzled protein and three Wnt proteins with distinct roles.
