Loss of endothelial Slit2 removes the chemo-attractive signal needed for Robo1-positive sympathetic axons to follow coronary vessels, resulting in reduced ventricular innervation.
A vessel on a chip microfluidic device recapitulates the main features of meningococcal vascular colonization, providing high time and space microscopy resolution of the infection process in 3D.
Lauren Thornton, Taylor Dick ... Christofer J Clemente
Postural adjustments that reduce ankle leverage in kangaroos enhance tendon stress and elastic energy storage at higher speeds, providing energetic efficiency during hopping but potentially constraining the maximum size achievable by large species.
Combined with high-throughput yeast genetics, a split green fluorescent protein encoded directly in the mitochondrial DNA helps to identify targeting signals and functions of dually localized proteins.
Pyruvate dictates redox balance and cell size, establishing metabolism as a dominant regulator of cellular fitness, unveiling new strategies to modulate cancer, regeneration, and diabetes.
