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    1. Neuroscience

    Neocortical Layer-5 tLTD Relies on Non-Ionotropic Presynaptic NMDA Receptor Signaling

    Aurore Thomazeau, Sabine Rannio ... P Jesper Sjöström
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Developmental Biology
    2. Neuroscience

    Commissureless acts as a substrate adapter in a conserved Nedd4 E3 ubiquitin ligase pathway to promote axon growth across the midline

    Kelly G Sullivan, Greg J Bashaw
    Commissureless works with the Nedd4 E3 ubiquitin ligase to transiently degrade the Robo1 receptor to allow commissural axons to cross the midline.
    Version of Record
    Research Article
    • Fundamental
    • Compelling
    • Convincing
    1. Cancer Biology
    2. Medicine

    Molecular feature-based classification of retroperitoneal liposarcoma: a prospective cohort study

    Mengmeng Xiao, Xiangji Li ... Li Min
    Identification of two molecularly distinct retroperitoneal liposarcoma subtypes, stratifiable via LEP and PTTG1 biomarkers, enables prognosis prediction and informs precision surgical strategies to improve clinical outcomes.
    1. Neuroscience

    Network segregation is associated with processing speed in the cognitively healthy oldest-old

    Sara A Nolin, Mary E Faulkner ... Kristina M Visscher
    Greater differentiation of brain networks is a hallmark of good cognitive functioning among individuals who have avoided neurodegenerative disease and live longer than a typical human lifespan.
    1. Neuroscience

    Cross-modal interaction of Alpha Activity does not reflect inhibition of early sensory processing: A frequency tagging study using EEG and MEG

    Marion Brickwedde, Rupali Limachya ... Ali Mazaheri
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Computational and Systems Biology

    Unsupervised reference-free inference reveals unrecognized regulated transcriptomic complexity in human single cells

    Roozbeh Dehghannasiri, George Henderson ... Julia Salzman
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Evolutionary Biology

    Forecasting protein evolution by integrating birth-death population models with structurally constrained substitution models

    David Ferreiro, Luis Daniel González-Vázquez ... Miguel Arenas
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics

    Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome

    Tanja Nielsen, Anaïs Kervadec ... Alexandre R Colas
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Cancer Biology

    Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

    Chong Zhang, Zuoyan Zhang ... Yangling Li
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape

    Ursula E Schoeberl, Johanna Fitz ... Rushad Pavri
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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