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Page 48 of 1,811
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

    Soumajit Dutta, Diwakar Shukla
    New psychoactive substances activate cannabinoid receptors using distinct ligand-receptor interactions.
    1. Biochemistry and Chemical Biology

    Insight into the bioactivity and action mode of betulin, a candidate aphicide from plant metabolite, against aphids

    Junxiu Wang, Matthana Klakong ... Hong Zhou
    The insecticidal activity of betulin, a plant-derived metabolite, against the peach aphid depends on specific targeting and inhibition of MpGABR.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Short heat shock factor A2 regulates heat resistance and growth balance in Arabidopsis

    Wanxia Chen, Jiaqi Zhao ... Xiaoting Qi
    Short heat shock factor variants prevent hyperactivation of thermotolerance through a noncanonical heat shock response, thereby balancing heat stress response and plant growth.
    1. Biochemistry and Chemical Biology

    Engineering NIR-sighted bacteria

    Stefanie SM Meier, Michael Hörzing ... Andreas Möglich
    Custom-tailored bathy-phytochromes control bacterial gene expression by near-infrared light while exhibiting minimal response to red light, thus unlocking innovative application scenarios.
    1. Neuroscience

    Relative timescale of channel voltage dependence and channel density regulation impacts assembly and recovery of activity

    Yugarshi Mondal, Ronald L Calabrese, Eve Marder
    Ion channel voltage-dependence alterations can shape intrinsic homeostatic plasticity, even if operating faster than other intrinsic regulatory processes—where timescale separation would suggest its influence should be negligible.
    1. Cell Biology

    Distinct functions of cardiac β-adrenergic receptors in the T-tubule vs. outer surface membrane

    George WP Madders, Marion Barthé ... Rodolphe Fischmeister
    A size exclusion strategy using PEGylation of isoprenaline allowed to demonstrate that cardiac β-adrenergic receptors located in the outer surface membrane control mainly cAMP/PKA in the cytosol while those located in the T-tubule membrane control cAMP/PKA in the nucleus.
    1. Genetics and Genomics

    Monocyte-endothelial interactions as a targetable node in clonal hematopoiesis-mediated cardiovascular disease

    Alyssa C Parker, J Brett Heimlich ... Alexander G Bick
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Unbend: Correction of local beam-induced sample motion in cryo-EM images using a 3D spline model

    Lingli Kong, Ximena Zottig ... Nikolaus Grigorieff
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β

    Kanako Shinno, Yuri Miura ... Kanae Ando
    Revised
    Reviewed Preprint v4
    Updated
    • Useful
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation

    Takashi Hotta, Morgan L Pimm ... Kristen J Verhey
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling