The oligomerization domain of 53BP1, a key DNA repair protein, is a trimer which binds the dimeric hub protein LC8 by a novel mechanism to form dynamic heterogeneous complexes.
Swagata Halder, Deepak Velgapuni Raya, Devarajan Sridharan
The attentional blink selectively impairs one component of attention, and impacts both target detection and discrimination via separable neural signatures.
Cecilia Tubert, Rodrigo Manuel Paz ... Mario Gustavo Murer
Restoring the Kv1-mediated pause in striatal cholinergic interneurons by reducing D5 receptor activity may help recover striatal function lost in dyskinetic parkinsonian mice.
Self-supervised deep learning models can accurately perform 3D segmentation of cell nuclei in complex biological tissues, enabling scalable analysis in settings with limited or no ground truth annotations.
AlphaFold-guided in vitro and in vivo analyses establish the mechanism of ULK complex formation and provide a structural basis for understanding its role in mammalian autophagy initiation.
