Browse our latest research

Page 68 of 1,756
    1. Neuroscience

    Brain dynamics and spatiotemporal trajectories during threat processing

    Joyneel Misra, Luiz Pessoa
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    Overt visual attention modulates decision-related signals in ventral and dorsal medial prefrontal cortex

    Blair Shevlin, Rachael Gwinn ... Ian Krajbich
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

    Jessica A Haley, Tianyi Chen ... Sreekanth H Chalasani
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

    Katerina Rademacher, Zak Doric ... Ken Nakamura
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Neuroscience

    CO2-dependent opening of Connexin 43 hemichannels

    Valentin-Mihai Dospinescu, Alexander Mascarenhas ... Nicholas Dale
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology

    TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

    Qianqian Ju, Wenjing Sheng ... Cheng Sun
    TAK1 plays a negative role in esophageal squamous cancer cell metastasis, which depends on the TAK1-induced phosphorylation of PLCE1 at S1060 and subsequent inhibition of PIP2 hydrolysis.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry

    Douwe Schulte, Marta Šiborová ... Joost Snijder
    Germline V-gene usage can be inferred from cryoEM reconstructions of antigen-antibody complexes to guide de novo antibody sequencing of complex mixtures by mass spectrometry.
    1. Medicine
    2. Neuroscience

    Simply crushed zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice

    Tomohiro Umeda, Ayumi Sakai ... Takami Tomiyama
    Simply crushed zizyphi spinosi semen not only ameliorates Aβ, tau, and α-synuclein pathology in dementia model mice, but also rejuvenates brain function by suppressing cellular senescence in normal aged mice.
    1. Chromosomes and Gene Expression

    SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing

    Ashwin Govindan, Nicholas K Conrad
    SFSWAP was identified in a genetic screen to negatively regulate splicing of OGT and other mRNAs primarily by regulating intron retention and exon skipping.
    1. Neuroscience

    Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling

    Benjamin Le Gac, Marine Tournissac ... Bruno Cauli
    Increased neuronal activity of cortical pyramidal cells can paradoxically reduce cerebral blood flow via vasoconstriction mediated by glutamate and lipid messengers.