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    1. Evolutionary Biology

    On the nature of the earliest known lifeforms

    Dheeraj Kanaparthi, Frances Westall ... Tillmann Lueders
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with the nuclear speckle

    Chiara Tomasini, Celine Cuche ... Francesca Di Nunzio
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells

    Mate Sumegi, Gaspar Olah ... Zoltan Nusser
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Neuroscience

    Human Brain Ancestral Barcodes

    Darryl Shibata
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of adapting pathogens and host immunity

    Pierre Barrat-Charlaix, Richard A Neher
    Diverse histories of viral exposure, for example in individuals of different age, makes viral evolution less predictable with features of adaptive and neutral evolution.
    1. Structural Biology and Molecular Biophysics

    N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

    Chuchu Wang, Chunyu Zhao ... Cong Liu
    NMR and clustering results show that N-terminal acetylation of α-syn enhances its binding to the neutral phospholipid lysophosphatidylcholine, thereby promoting its function of clustering synaptic vesicles.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

    Ananda Kishore Mukherjee, Subhajit Dutta ... Shantanu Chowdhury
    Telomere-sensitive regulation of IL1R1 by the shelterin protein TERF2 modulates tumour macrophage inflitration in triple-negative breast cancer.
    1. Neuroscience

    Three-dimensional single-cell transcriptome imaging of thick tissues

    Rongxin Fang, Aaron Halpern ... Xiaowei Zhuang
    By integrating multiplexed error-robust fluorescence in situ hybridization (MERFISH), deep learning, optical sectioning, and protocol optimization, thick-tissue 3D MERFISH allows volumetric single-cell transcriptome imaging of thick-tissue samples, broadening the scope of applications of spatial genomics.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

    Raji E Joseph, Thomas E Wales ... Amy H Andreotti
    The clinically approved BTK kinase active site inhibitors alter the conformational equilibrium of full-length BTK in distinct and unexpected ways.
    1. Cancer Biology
    2. Cell Biology

    TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma

    Maojin Tian, Le Yang ... Peiqing Zhao
    The TIPE/PKM2/HIF-1α signaling pathway plays a crucial role in enhancing cancer stem cell properties by facilitating glycolysis, thereby presenting a promising therapeutic target for melanoma intervention.
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