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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers

    Xiaoyu Yu, Yuanjun He ... Douglas J Kojetin
    Resolving the mechanism of RXR ligand-dependent NR4A-RXR nuclear receptor heterodimer activation requires a diverse ligand set that includes heterodimer-selective agonists.
    1. Cell Biology

    The FAM53C/DYRK1A axis regulates the G1/S transition of the cell cycle

    Taylar Hammond, Jong Bin Choi ... Julien Sage
    The poorly characterized FAM53C protein is an inhibitor of the DYRK1A kinase and governs the G1/S transition of the cell cycle.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Unbend, correction of local beam-induced sample motion in cryo-EM images using a 3D spline model

    Lingli Kong, Ximena Zottig ... Nikolaus Grigorieff
    Movie alignment software uses a 3D spline model to capture beam-induced motion in cryo-electron microscopy movie frames, correct local sample distortions, and improve two-dimensional template matching signal-to-noise ratios in the corrected images.
    1. Cell Biology
    2. Developmental Biology

    Prickle and Ror modulate Dishevelled-Vangl interaction to regulate non-canonical Wnt signaling during convergent extension in Xenopus

    Hwa-seon Seo, Deli Yu ... Jianbo Wang
    During convergent extension morphogenesis, non-canonical Wnt induces the signal transducer Dishevelled to transition from Vangl to Frizzled, a process that is inhibited by Prickle but facilitated by the co-receptor Ror.
    1. Cancer Biology

    Integrated Human Transcriptomics Identifies Fallopian Tube Progenitors as Plausible Precursors of High-Grade Serous Ovarian Cancer

    Qian Li, Keren Cheng ... Wei Yan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles

    Zahra Seraj, Ximena Zottig ... Andrei A Korostelev
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    The structure of Egalitarian in complex with the K10 mRNA localization signal reveals a modular binding surface required for function

    Zebin Hong, Li Jin ... Fulvia Bono
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Stem Cells and Regenerative Medicine

    Synergistic Inhibition of Notch Signaling and Forced Cell Cycle Re-entry Drive Müller Glia Reprogramming in Uninjured Mouse Retina

    Baoshan Liao, Chengshang Lyu ... Wenjun Xiong
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Optics-free reconstruction of shapes, images and volumes with DNA barcode proximity graphs

    Hanna Liao, Sanjay Kottapalli ... Sanjay Srivatsan
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    The Ingestive Response Reflects Neural Dynamics in Gustatory Cortex

    Natasha Baas-Thomas, Abuzar Mahmood ... Donald B Katz
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
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