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    1. Cancer Biology

    KDM5 demethylases suppress R-loop-mediated “viral mimicry” and DNA damage in breast cancer cells

    Lena Lau, Kurt Henderson ... Marie Classon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Single-cell type analysis of wing premotor circuits in the ventral nerve cord of Drosophila melanogaster

    Erica Ehrhardt, Samuel C Whitehead ... Wyatt Korff
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Anti-drift pose tracker (ADPT), a transformer-based network for robust animal pose estimation cross-species

    Guoling Tang, Yaning Han ... Pengfei Wei
    ADPT enhances the robustness of animal pose estimation by minimizing keypoint tracking drift, enabling more accurate multi-animal tracking and facilitating refined behavioral analysis across species.
    1. Cancer Biology

    The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells

    Jie Fang, Shivendra Singh ... Jun Yang
    Drastic differences in genetic and epigenetic fitness of MYC-driven cancer cells in 3D vs 2D culture.
    Version of Record
    Research Article
    • Important
    • Convincing
    • Incomplete
    1. Immunology and Inflammation

    RAG suppresses group 2 innate lymphoid cells

    Aaron M Ver Heul, Madison Mack ... Brian S Kim
    Developmental imprinting controls innate type 2 immune function and allergic inflammation.
    1. Cell Biology

    Reprograming gene expression in ‘hibernating’ C. elegans involves the IRE-1/XBP-1 pathway

    Melanie Lianne Engelfriet, Yanwu Guo ... Rafal Ciosk
    Gene expression in nematodes during cold-induced dormancy is proposed to be regulated at the transcription level, partly involving the activation of unfolded protein response (UPR) through the IRE-1/XBP-1 signaling pathway.
    1. Developmental Biology
    2. Evolutionary Biology

    Differences in size and number of embryonic type II neuroblast lineages correlate with divergent timing of central complex development between beetle and fly

    Simon Rethemeier, Sonja Fritzsche ... Vera S Hunnekuhl
    Genetic labeling and molecular analyses characterize the dynamics of embryonic central complex-forming type II neuroblast lineages in Tribolium castaneum.
    1. Cell Biology

    Emergence of Dip2-mediated specific DAG-based PKC signalling axis in eukaryotes

    Sakshi Shambhavi, Sudipta Mondal ... Rajan Sankaranarayanan
    Dip2 regulates PKC signalling through specific DAG acyl chain compositions—a crucial pathway, which emerged approximately 1.2 billion years ago, marking the advent of selective DAG-based signalling in eukaryotes.
    1. Cell Biology
    2. Developmental Biology

    Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development

    Qian Wang, Hongge Li ... Xin Zhang
    FGF signaling drives lens development by recruiting Grb2 through Shc1, Frs2, and Shp2 to regulate transcription and cytoskeletal arrangements.
    1. Ecology

    Quantifying feral pig interactions to inform disease transmission networks

    Tatiana Proboste, Abigail Turnlund ... Ricardo J Soares-Magalhaes
    Distinct seasonal peaks and sex-specific interactions reveal that cohesive female groups drive rapid local spread while male connectors facilitate intergroup transmission, underscoring the need for tailored disease control strategies.