Genetic deficits in auditory sensory transduction evoke changes in development and maturation of synapses between inner hair cells and spiral ganglion neurons, which can be partially recovered using inner ear gene therapy.
Novel stimulation patterns and large-scale neural activity recording show that an input-specific supra-linear summation synthesizes a sparse, but comprehensive code of tactile and visual stimuli in the sensory cortex.
Specific localization of KRAS downstream target ARL4C with its novel interacting proteins was the active site of invasion of pancreatic cancer cell and induced metastasis.
Michael C Kiritsy, Katelyn McCann ... Andrew J Olive
Complex I of the mitochondrial respiratory chain is necessary for interferon gamma-mediated responses in antigen-presenting cells and is required for CD4+ T cell activation.
María J Conde-Dusman, Partha N Dey ... Isabel Perez-Otaño
Non-conventional NMDA receptors containing GluN3A subunits place constraints on the capacity of the brain to encode lasting memories through regulation of synaptic GIT1/mTOR signaling complexes.
Benedetta De Ponte Conti, Annarita Miluzio ... Sara Ricciardi
In the tumor microenvironment, only specific subsets of cytotoxic and immunosuppressive tumor-infiltrating lymphocytes are endowed with active translation.