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Page 715 of 1,745
    1. Immunology and Inflammation

    Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice

    Veronika Lang, Sebastian Ferencik ... Bert Maier
    Circadian clocks in murine myeloid cells are dispensable for circadian cytokine function, trafficking and endotoxic shock in response to LPS in vivo.
    1. Genetics and Genomics
    2. Neuroscience

    Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses

    John Lee, Kosuke Kawai ... Gwenaëlle SG Géléoc
    Genetic deficits in auditory sensory transduction evoke changes in development and maturation of synapses between inner hair cells and spiral ganglion neurons, which can be partially recovered using inner ear gene therapy.
    1. Neuroscience

    Synthesis of a comprehensive population code for contextual features in the awake sensory cortex

    Evan H Lyall, Daniel P Mossing ... Hillel Adesnik
    Novel stimulation patterns and large-scale neural activity recording show that an input-specific supra-linear summation synthesizes a sparse, but comprehensive code of tactile and visual stimuli in the sensory cortex.
    1. Cancer Biology
    2. Cell Biology

    Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion

    Akikazu Harada, Shinji Matsumoto ... Akira Kikuchi
    Specific localization of KRAS downstream target ARL4C with its novel interacting proteins was the active site of invasion of pancreatic cancer cell and induced metastasis.
    1. Immunology and Inflammation

    Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells

    Michael C Kiritsy, Katelyn McCann ... Andrew J Olive
    Complex I of the mitochondrial respiratory chain is necessary for interferon gamma-mediated responses in antigen-presenting cells and is required for CD4+ T cell activation.
    1. Immunology and Inflammation

    A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

    Michael C Kiritsy, Laurisa M Ankley ... Andrew J Olive
    Med16 and GSK3b regulate interferon gamma-mediated MHCII expression in macrophages and are required for CD4+ T cell activation.
    1. Neuroscience

    Opioid antagonism modulates wanting-related frontostriatal connectivity

    Alexander Soutschek, Susanna C Weber ... Philippe N Tobler
    Reducing activation of opioidergic receptors strengthens the communication between control and reward circuits in the brain during hedonic judgements.
    1. Cell Biology

    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly

    María J Conde-Dusman, Partha N Dey ... Isabel Perez-Otaño
    Non-conventional NMDA receptors containing GluN3A subunits place constraints on the capacity of the brain to encode lasting memories through regulation of synaptic GIT1/mTOR signaling complexes.
    1. Cell Biology
    2. Immunology and Inflammation

    mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion

    Benedetta De Ponte Conti, Annarita Miluzio ... Sara Ricciardi
    In the tumor microenvironment, only specific subsets of cytotoxic and immunosuppressive tumor-infiltrating lymphocytes are endowed with active translation.
    1. Neuroscience

    Urgency forces stimulus-driven action by overcoming cognitive control

    Christian H Poth
    Under time-pressure, human action is temporarily dominated by stimuli in the environment, and this results in behavior conflicting with current goals.